tert-butyl (2R,5R,3E)-2-{3-[N-[(benzyloxy)carbonyl]-N-[(2-nitrophenyl)sulfonyl]amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)hex-3-enoate

Base Information

Chemical Name:tert-butyl (2R,5R,3E)-2-{3-[N-[(benzyloxy)carbonyl]-N-[(2-nitrophenyl)sulfonyl]amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)hex-3-enoate
CAS No.:1361407-58-0
Molecular Formula:C₃₉H₄₉N₃O₁₁S
Molecular Weight:767.898
Hs Code.:

tert-butyl (2R,5R,3E)-2-{3-[N-[(benzyloxy)carbonyl]-N-[(2-nitrophenyl)sulfonyl]amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)hex-3-enoate

Synonyms:tert-butyl (2R,5R,3E)-2-{3-[N-[(benzyloxy)carbonyl]-N-[(2-nitrophenyl)sulfonyl]amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)hex-3-enoate

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Chemical Property of tert-butyl (2R,5R,3E)-2-{3-[N-[(benzyloxy)carbonyl]-N-[(2-nitrophenyl)sulfonyl]amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)hex-3-enoate

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Technology Process of tert-butyl (2R,5R,3E)-2-{3-[N-[(benzyloxy)carbonyl]-N-[(2-nitrophenyl)sulfonyl]amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)hex-3-enoate

There total 9 articles about tert-butyl (2R,5R,3E)-2-{3-[N-[(benzyloxy)carbonyl]-N-[(2-nitrophenyl)sulfonyl]amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)hex-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₃₉NO₆

: 245365-64-4
N-benzyloxycarbonyl-2-nitrobenzenesulfonamide

: 1361407-58-0
tert-butyl (2R,5R,3E)-2-{3-[N-[(benzyloxy)carbonyl]-N-[(2-nitrophenyl)sulfonyl]amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)hex-3-enoate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm2016914

Reference yield:

: 1361407-53-5
(3R,4R)-4-[N-(tert-butoxycarbonyl)amino]-5-(4-methoxyphenyl)pent-1-en-3-ol

: 1361407-58-0
tert-butyl (2R,5R,3E)-2-{3-[N-[(benzyloxy)carbonyl]-N-[(2-nitrophenyl)sulfonyl]amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)hex-3-enoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine; dmap / chloroform / 2 h / 0 °C

2.1: dimethylsulfide; ozone / ethyl acetate / 0.5 h / -78 - 0 °C

3.1: N-ethyl-N,N-diisopropylamine; lithium chloride / acetonitrile / 0.33 h / 0 °C / Inert atmosphere

3.2: 3 h / 0 °C / Inert atmosphere

4.1: methanol; potassium carbonate / 2 h / 0 - 20 °C

5.1: triethylamine / dichloromethane / 2 h / 0 °C

6.1: copper(l) cyanide; lithium chloride / tetrahydrofuran; diethyl ether; pentane / 1 h / -78 - 0 °C / Inert atmosphere

7.1: fluorosilicic acid; water / acetonitrile / 2 h / 0 - 20 °C

8.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 3 h / 0 °C / Inert atmosphere

With pyridine; methanol; dmap; fluorosilicic acid; dimethylsulfide; water; copper(l) cyanide; potassium carbonate; ozone; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium chloride; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; ethyl acetate; toluene; acetonitrile; pentane; 3.1: Horner-Wadsworth-Emmons olefination / 3.2: Horner-Wadsworth-Emmons olefination / 8.1: Mitsunobu reaction;
DOI:10.1021/jm2016914

Reference yield:

: 1361407-57-9
tert-butyl (2R,5R,3E)-5-[N-(tert-butoxycarbonyl)amino]-2-[3-(tert-butyldimethylsiloxy)propyl]-6-(4-methoxyphenyl)hex-3-enoate

: 1361407-58-0
tert-butyl (2R,5R,3E)-2-{3-[N-[(benzyloxy)carbonyl]-N-[(2-nitrophenyl)sulfonyl]amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)hex-3-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: fluorosilicic acid; water / acetonitrile / 2 h / 0 - 20 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 3 h / 0 °C / Inert atmosphere

With fluorosilicic acid; water; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; acetonitrile; 2: Mitsunobu reaction;
DOI:10.1021/jm2016914