1-Benzyl 5-Methyl N,N-bis(tert-butoxycarbonyl)-L-glutaMate

Base Information

Chemical Name:1-Benzyl 5-Methyl N,N-bis(tert-butoxycarbonyl)-L-glutaMate
CAS No.:1138018-24-2
Molecular Formula:C₂₃H₃₃NO₈
Molecular Weight:451.517
Hs Code.:
Mol file:1138018-24-2.mol

Synonyms:(S)-1-benzyl 5-methyl 2-(bis((tert-butoxy)carbonylamino))pentanedioate

Suppliers and Price of 1-Benzyl 5-Methyl N,N-bis(tert-butoxycarbonyl)-L-glutaMate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

TRC
1-Benzyl5-MethylN,N-Bis(tert-butoxycarbonyl)-L-glutamate
100mg
$ 695.00

Total 0 raw suppliers

Chemical Property of 1-Benzyl 5-Methyl N,N-bis(tert-butoxycarbonyl)-L-glutaMate

Chemical Property:

Purity/Quality:: 1-Benzyl5-MethylN,N-Bis(tert-butoxycarbonyl)-L-glutamate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 1-Benzyl 5-methyl N,N-bis(tert-butoxycarbonyl)-L-glutamate is used in the synthesis of Isodesmosine Chloride (I815050), which is a component of elastin.

Technology Process of 1-Benzyl 5-Methyl N,N-bis(tert-butoxycarbonyl)-L-glutaMate

There total 2 articles about 1-Benzyl 5-Methyl N,N-bis(tert-butoxycarbonyl)-L-glutaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 132245-78-4
(S)-2-tert-butoxycarbonylaminopentanedioic acid 1-benzyl ester 5-methyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 1138018-24-2
(S)-1-benzyl 5-methyl 2-(bis((tert-butoxy)carbonylamino))pentanedioate

Guidance literature:: With dmap; In acetonitrile; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1016/j.tetasy.2011.03.002

Reference yield:

: 30924-93-7
Boc-Glu-OBn

: 1138018-24-2
(S)-1-benzyl 5-methyl 2-(bis((tert-butoxy)carbonylamino))pentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

2: dmap / acetonitrile / 20 h / 20 °C / Inert atmosphere

With dmap; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.tetasy.2011.03.002

Reference yield: 100.0%

: 1138018-24-2
(S)-1-benzyl 5-methyl 2-(bis((tert-butoxy)carbonylamino))pentanedioate

: 1138018-25-3
2-(S)-[bis(tert-butoxycarbonyl)amino]-5-oxo-pentanoic acid benzyl ester

Guidance literature:: (S)-1-benzyl 5-methyl 2-(bis((tert-butoxy)carbonylamino))pentanedioate; With diisobutylaluminium hydride; In diethyl ether; hexane; at -78 ℃;

With acetic acid; In diethyl ether; hexane; at -78 ℃;