3-((4-(2-morpholino-4-oxo-1,4-dihydroquinolin-8-yl)-1H-1,2,3-triazol-1-yl)methyl)benzoic acid

Base Information

Chemical Name:3-((4-(2-morpholino-4-oxo-1,4-dihydroquinolin-8-yl)-1H-1,2,3-triazol-1-yl)methyl)benzoic acid
CAS No.:1380227-13-3
Molecular Formula:C₂₃H₂₁N₅O₄
Molecular Weight:431.451
Hs Code.:

Synonyms:3-((4-(2-morpholino-4-oxo-1,4-dihydroquinolin-8-yl)-1H-1,2,3-triazol-1-yl)methyl)benzoic acid

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Chemical Property of 3-((4-(2-morpholino-4-oxo-1,4-dihydroquinolin-8-yl)-1H-1,2,3-triazol-1-yl)methyl)benzoic acid

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Technology Process of 3-((4-(2-morpholino-4-oxo-1,4-dihydroquinolin-8-yl)-1H-1,2,3-triazol-1-yl)methyl)benzoic acid

There total 6 articles about 3-((4-(2-morpholino-4-oxo-1,4-dihydroquinolin-8-yl)-1H-1,2,3-triazol-1-yl)methyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 905973-32-2
3-(azidomethyl)benzenecarboxylic acid

: 1380228-35-2
8-ethynyl-2-morpholinoquinolin-4(1H)-one

: 1380227-13-3
3-((4-(2-morpholino-4-oxo-1,4-dihydroquinolin-8-yl)-1H-1,2,3-triazol-1-yl)methyl)benzoic acid

Guidance literature:: With copper diacetate; sodium L-ascorbate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In tetrahydrofuran; water; at 20 ℃;
DOI:10.1002/cmdc.201700340

Reference yield:

: 1380228-31-8
8-iodo-2-morpholinoquinolin-4(1H)-one

: 1380227-13-3
3-((4-(2-morpholino-4-oxo-1,4-dihydroquinolin-8-yl)-1H-1,2,3-triazol-1-yl)methyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / toluene; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

2: methanol; potassium carbonate / 3 h / 20 °C

3: tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; sodium L-ascorbate; copper diacetate / tetrahydrofuran; water / 20 °C

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; copper diacetate; potassium carbonate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201700340

Reference yield:

: 1380228-33-0
2-morpholino-8-((trimethylsilyl)ethynyl)quinolin-4(1H)-one

: 1380227-13-3
3-((4-(2-morpholino-4-oxo-1,4-dihydroquinolin-8-yl)-1H-1,2,3-triazol-1-yl)methyl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; potassium carbonate / 3 h / 20 °C

2: tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; sodium L-ascorbate; copper diacetate / tetrahydrofuran; water / 20 °C

With methanol; copper diacetate; potassium carbonate; sodium L-ascorbate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In tetrahydrofuran; water;
DOI:10.1002/cmdc.201700340