1-[5-O-(4,4-dimethoxytrityl)-2-deoxy-β-D-erythro-pentofuranosyl]-4-(3,3,4,4-tetramethyl-2,5-dioxopyrrolidin-1-yl)-1H-imidazo[4,5-c]pyridine

Base Information

Chemical Name:1-[5-O-(4,4-dimethoxytrityl)-2-deoxy-β-D-erythro-pentofuranosyl]-4-(3,3,4,4-tetramethyl-2,5-dioxopyrrolidin-1-yl)-1H-imidazo[4,5-c]pyridine
CAS No.:1266379-69-4
Molecular Formula:C₄₀H₄₂N₄O₇
Molecular Weight:690.796
Hs Code.:

Synonyms:1-[5-O-(4,4-dimethoxytrityl)-2-deoxy-β-D-erythro-pentofuranosyl]-4-(3,3,4,4-tetramethyl-2,5-dioxopyrrolidin-1-yl)-1H-imidazo[4,5-c]pyridine

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Chemical Property of 1-[5-O-(4,4-dimethoxytrityl)-2-deoxy-β-D-erythro-pentofuranosyl]-4-(3,3,4,4-tetramethyl-2,5-dioxopyrrolidin-1-yl)-1H-imidazo[4,5-c]pyridine

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Technology Process of 1-[5-O-(4,4-dimethoxytrityl)-2-deoxy-β-D-erythro-pentofuranosyl]-4-(3,3,4,4-tetramethyl-2,5-dioxopyrrolidin-1-yl)-1H-imidazo[4,5-c]pyridine

There total 4 articles about 1-[5-O-(4,4-dimethoxytrityl)-2-deoxy-β-D-erythro-pentofuranosyl]-4-(3,3,4,4-tetramethyl-2,5-dioxopyrrolidin-1-yl)-1H-imidazo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1266379-68-3
1-[2-deoxy-β-D-erythro-pentofuranosyl]-4-(3,3,4,4-tetramethyl-2,5-dioxopyrrolidin-1-yl)-1H-imidazo[4,5-c]pyridine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1266379-69-4
1-[5-O-(4,4-dimethoxytrityl)-2-deoxy-β-D-erythro-pentofuranosyl]-4-(3,3,4,4-tetramethyl-2,5-dioxopyrrolidin-1-yl)-1H-imidazo[4,5-c]pyridine

Guidance literature:: With pyridine; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/ja1103684

Reference yield:

: 1266379-66-1
N-(1H-imidazo[4,5-c]pyridin-4-yl)-2,2,3,3-tetramethylsuccinimide

: 1266379-69-4
1-[5-O-(4,4-dimethoxytrityl)-2-deoxy-β-D-erythro-pentofuranosyl]-4-(3,3,4,4-tetramethyl-2,5-dioxopyrrolidin-1-yl)-1H-imidazo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / acetonitrile; mineral oil / 0.5 h / 20 °C / Inert atmosphere

1.2: 8 h / 20 °C / Inert atmosphere

2.1: ammonia / methanol / 20 h / 20 °C / Inert atmosphere

3.1: pyridine / 4 h / 20 °C / Inert atmosphere

With pyridine; ammonia; sodium hydride; In methanol; acetonitrile; mineral oil;
DOI:10.1021/ja1103684

Reference yield:

: 6811-77-4
3-deazaadenine

: 1266379-69-4
1-[5-O-(4,4-dimethoxytrityl)-2-deoxy-β-D-erythro-pentofuranosyl]-4-(3,3,4,4-tetramethyl-2,5-dioxopyrrolidin-1-yl)-1H-imidazo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 h / Reflux; Inert atmosphere

1.2: 2 h / Reflux; Inert atmosphere

2.1: sodium hydride / acetonitrile; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2.2: 8 h / 20 °C / Inert atmosphere

3.1: ammonia / methanol / 20 h / 20 °C / Inert atmosphere

4.1: pyridine / 4 h / 20 °C / Inert atmosphere

With pyridine; ammonia; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; acetonitrile; mineral oil;
DOI:10.1021/ja1103684