1-(2-amino-3, 5-difluorobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline

Base Information

Chemical Name:1-(2-amino-3, 5-difluorobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline
CAS No.:1315179-70-4
Molecular Formula:C₂₂H₁₉F₂N₃O₂
Molecular Weight:395.409
Hs Code.:

Synonyms:1-(2-amino-3, 5-difluorobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline

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Chemical Property of 1-(2-amino-3, 5-difluorobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline

Chemical Property:

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Technology Process of 1-(2-amino-3, 5-difluorobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline

There total 6 articles about 1-(2-amino-3, 5-difluorobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16114-47-9
3,5-dimethylisoxazole-4-boronic acid

: 1315180-11-0
1-(2-amino-3, 5-difluorobenzyl)-7-bromo-2-methyl-1, 4-dihydro-4-oxoquinoline

: 1315179-70-4
1-(2-amino-3, 5-difluorobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline

Guidance literature:: With sodium hydrogencarbonate; triphenylphosphine; palladium diacetate; In ethanol; water; toluene; for 2h; Reflux; Inert atmosphere;

Reference yield:

: 625446-22-2
4-bromo-2-fluoroacetophenone

: 1315179-70-4
1-(2-amino-3, 5-difluorobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3.25 h / Reflux

2.1: borane-THF / tetrahydrofuran / 2.53 h / Inert atmosphere; Reflux

2.2: 0.75 h / Reflux; Inert atmosphere

2.3: 2.33 h / 49 - 75 °C

3.1: potassium carbonate / dimethyl sulfoxide / 4.25 h / 48 - 65 °C

4.1: triphenylphosphine; sodium hydrogencarbonate / palladium diacetate / toluene; ethanol; water / 2 h / Reflux; Inert atmosphere

With borane-THF; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; palladium diacetate; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; toluene;

Reference yield:

: 868596-13-8
3,5-difluoro-2-nitrobenzonitrile

: 1315179-70-4
1-(2-amino-3, 5-difluorobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol; water; ammonium chloride; iron / 2.33 h / Reflux

2.1: borane-THF / tetrahydrofuran / 2.53 h / Inert atmosphere; Reflux

2.2: 0.75 h / Reflux; Inert atmosphere

2.3: 2.33 h / 49 - 75 °C

3.1: potassium carbonate / dimethyl sulfoxide / 4.25 h / 48 - 65 °C

4.1: triphenylphosphine; sodium hydrogencarbonate / palladium diacetate / toluene; ethanol; water / 2 h / Reflux; Inert atmosphere

With borane-THF; ethanol; water; iron; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; triphenylphosphine; palladium diacetate; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; toluene;