(R)-3-((S)-1-(4-bromophenyl)-2-nitroethyl)-3-chloroindolin-2-one

Base Information

• Chemical Name: (R)-3-((S)-1-(4-bromophenyl)-2-nitroethyl)-3-chloroindolin-2-one
• CAS No.: 1398566-58-9
• Molecular Formula: C₁₆H₁₂BrClN₂O₃
• Molecular Weight: 395.64
• Mol file: 1398566-58-9.mol

Synonyms:(R)-3-((S)-1-(4-bromophenyl)-2-nitroethyl)-3-chloroindolin-2-one

Chemical Property of (R)-3-((S)-1-(4-bromophenyl)-2-nitroethyl)-3-chloroindolin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-((S)-1-(4-bromophenyl)-2-nitroethyl)-3-chloroindolin-2-one

There total 2 articles about (R)-3-((S)-1-(4-bromophenyl)-2-nitroethyl)-3-chloroindolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

rac-3-chloroindolin-2-one (68235-96-1) + (E)-1-bromo-4-(2-nitrovinyl)benzene (3156-37-4,5153-71-9) → (R)-3-((S)-1-(4-bromophenyl)-2-nitroethyl)-3-chloroindolin-2-one (1398566-58-9)

Guidance literature:

With C₄₉H₃₇F₆N₃O₂; In dichloromethane; at 20 ℃; for 2h; enantioselective reaction;

Reference yield:

rac-3-chloroindolin-2-one (68235-96-1) + (E)-1-bromo-4-(2-nitrovinyl)benzene (3156-37-4,5153-71-9) → (R)-3-((S)-1-(4-bromophenyl)-2-nitroethyl)-3-chloroindolin-2-one (1398566-58-9) + C16H12BrClN2O3

Guidance literature:

With C₃₂H₃₀F₆N₄O₃; In chloroform; at 4 ℃; for 24h; Overall yield = 96 %; Overall yield = 38 mg;

DOI:10.1021/ol302245b DOI:10.1021/ol302245b

upstream raw materials:

rac-3-chloroindolin-2-one

(E)-1-bromo-4-(2-nitrovinyl)benzene