Technology Process of Acetic acid (R)-1-[(1S,2R)-2-hydroxy-1-((2S,3R,4S,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxymethyl)-heptadecylcarbamoyl]-pentacosyl ester
There total 10 articles about Acetic acid (R)-1-[(1S,2R)-2-hydroxy-1-((2S,3R,4S,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxymethyl)-heptadecylcarbamoyl]-pentacosyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 2-chloro-1-methylpyridinium iodide, n-tributylamine / CH2Cl2 / 2 h / Heating
2: HCO2H / 10percent Pd/C / tetrahydrofuran; propan-1-ol / 16 h / 45 °C
3: 1.) SnCl2, AgClO4, 4 Angstroem sieves / 1.) THF, RT, 30 min, 2.) THF, from -10 deg C to RT, 2 h
With
formic acid; tributyl-amine; 4 A molecular sieve; 2-chloro-1-methyl-pyridinium iodide; silver perchlorate; tin(ll) chloride;
palladium on activated charcoal;
In
tetrahydrofuran; propan-1-ol; dichloromethane;
DOI:10.1021/jm00012a018
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) cerebrine-E yeast, aq. HCl, 2.) KOH, aq. EtOH, 3.) pyridine
2: 2-chloro-1-methylpyridinium iodide, n-tributylamine / CH2Cl2 / 2 h / Heating
3: HCO2H / 10percent Pd/C / tetrahydrofuran; propan-1-ol / 16 h / 45 °C
4: 1.) SnCl2, AgClO4, 4 Angstroem sieves / 1.) THF, RT, 30 min, 2.) THF, from -10 deg C to RT, 2 h
With
pyridine; hydrogenchloride; potassium hydroxide; formic acid; tributyl-amine; ethanol; 4 A molecular sieve; cerebrine-E yeast; 2-chloro-1-methyl-pyridinium iodide; silver perchlorate; tin(ll) chloride;
palladium on activated charcoal;
In
tetrahydrofuran; propan-1-ol; dichloromethane;
DOI:10.1021/jm00012a018
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 12 h / 150 °C
2: 1.) nBuLi / 1.) hexane, THF, -10 deg C, 30 min, 2.) hexane, THF, RT, 16 h
3: 89 percent / pyridine / 1.5 h / 0 - 20 °C
4: 78 percent / NaN3 / dimethylformamide / 16 h / 100 °C
5: H2 / Pd/C / tetrahydrofuran; propan-1-ol / 16 h
6: 2-chloro-1-methylpyridinium iodide, n-tributylamine / CH2Cl2 / 2 h / Heating
7: HCO2H / 10percent Pd/C / tetrahydrofuran; propan-1-ol / 16 h / 45 °C
8: 1.) SnCl2, AgClO4, 4 Angstroem sieves / 1.) THF, RT, 30 min, 2.) THF, from -10 deg C to RT, 2 h
With
pyridine; n-butyllithium; formic acid; sodium azide; tributyl-amine; 4 A molecular sieve; 2-chloro-1-methyl-pyridinium iodide; hydrogen; silver perchlorate; tin(ll) chloride;
palladium on activated charcoal;
In
tetrahydrofuran; propan-1-ol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00012a018
