Technology Process of 1,2,3,4,6,7,8,9-octahydro-1,6-dioxo-2-benzyl-5-(2-acetoxyphenoxy)-9-carbomethoxyisoquinoline
There total 9 articles about 1,2,3,4,6,7,8,9-octahydro-1,6-dioxo-2-benzyl-5-(2-acetoxyphenoxy)-9-carbomethoxyisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) NaH / 1.) THF, DMF, RT, 1.5 h, 2.) RT, 12 h
2: 81 percent / H2 / 5percent Pd/C / ethyl acetate; acetic acid / 4 h / 760 Torr
3: 59 percent / KH / tetrahydrofuran / 1.) RT, 3 h, 2.) reflux, 19 h
4: 1.) H2O, AcOH, 2.) pyridine / 1.) THF, 80 deg C, 15 h, 2.) CH2Cl2, RT, 12 h
With
pyridine; water; hydrogen; potassium hydride; sodium hydride; acetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; acetic acid; ethyl acetate;
DOI:10.1021/jo00202a014
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 81 percent / H2 / 5percent Pd/C / ethyl acetate; acetic acid / 4 h / 760 Torr
2: 59 percent / KH / tetrahydrofuran / 1.) RT, 3 h, 2.) reflux, 19 h
3: 1.) H2O, AcOH, 2.) pyridine / 1.) THF, 80 deg C, 15 h, 2.) CH2Cl2, RT, 12 h
With
pyridine; water; hydrogen; potassium hydride; acetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; acetic acid; ethyl acetate;
DOI:10.1021/jo00202a014
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 59 percent / KH / tetrahydrofuran / 1.) RT, 3 h, 2.) reflux, 19 h
2: 1.) H2O, AcOH, 2.) pyridine / 1.) THF, 80 deg C, 15 h, 2.) CH2Cl2, RT, 12 h
With
pyridine; water; potassium hydride; acetic acid;
In
tetrahydrofuran;
DOI:10.1021/jo00202a014
