3-allyl-N-[1S-(3-allylphenoxymethyl)-4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(methanesulphonylmethylamino)-benzamide

Base Information

Chemical Name:3-allyl-N-[1S-(3-allylphenoxymethyl)-4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(methanesulphonylmethylamino)-benzamide
CAS No.:1079398-78-9
Molecular Formula:C₄₀H₅₂N₄O₈S
Molecular Weight:748.941
Hs Code.:

3-allyl-N-[1S-(3-allylphenoxymethyl)-4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(methanesulphonylmethylamino)-benzamide

Synonyms:3-allyl-N-[1S-(3-allylphenoxymethyl)-4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(methanesulphonylmethylamino)-benzamide

Suppliers and Price of 3-allyl-N-[1S-(3-allylphenoxymethyl)-4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(methanesulphonylmethylamino)-benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-allyl-N-[1S-(3-allylphenoxymethyl)-4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(methanesulphonylmethylamino)-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-allyl-N-[1S-(3-allylphenoxymethyl)-4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(methanesulphonylmethylamino)-benzamide

There total 16 articles about 3-allyl-N-[1S-(3-allylphenoxymethyl)-4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(methanesulphonylmethylamino)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 847157-50-0
3-allyl-5-[methyl(methylsulfonyl)amino]benzoic acid

: 1079398-77-8
C₂₈H₃₉N₃O₅

: 1079398-78-9
3-allyl-N-[1S-(3-allylphenoxymethyl)-4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(methanesulphonylmethylamino)-benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

Reference yield:

: 2398-37-0
3-methoxyphenyl bromide

: 1079398-78-9
3-allyl-N-[1S-(3-allylphenoxymethyl)-4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(methanesulphonylmethylamino)-benzamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: magnesium / iodine / tetrahydrofuran / 4 h / Heating / reflux

2.1: boron tribromide / dichloromethane / 3 h / 0 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 20 - 110 °C

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.25 h / -15 °C

4.2: 12.5 h / -15 - 20 °C

5.1: hydrogenchloride / 3 h / 0 - 20 °C

6.1: silver(l) oxide / N,N-dimethyl-formamide / 14 h / 20 °C

7.1: sulfuric acid; water / 1,4-dioxane / 3 h / 20 °C / Heating / reflux

8.1: dipyridinium dichromate / dichloromethane / 10 h / 0 - 20 °C / Molecular sieve

9.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 70 °C

10.1: triphenylphosphine / methanol; water / 17 h

11.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

With 2-hydroxypyridin; hydrogenchloride; dipyridinium dichromate; di-isopropyl azodicarboxylate; sulfuric acid; water; boron tribromide; potassium carbonate; magnesium; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; silver(l) oxide; iodine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 79233-85-5
O-[1,2:5,6-di-O-isopropylidene-α-D-glucofuranosyl] 1H-imidazole-1-carbothioate

: 1079398-78-9
3-allyl-N-[1S-(3-allylphenoxymethyl)-4R-(1S-benzylcarbamoyl-2-methylpropylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(methanesulphonylmethylamino)-benzamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: tri-n-butyl-tin hydride / 2,2'-azobis(isobutyronitrile) / toluene / 6.5 h / Heating / reflux

2.1: water; acetic acid / 10 h / 0 - 20 °C

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / chloroform / 10 h / Heating / reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 20 - 110 °C

5.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.25 h / -15 °C

5.2: 12.5 h / -15 - 20 °C

6.1: hydrogenchloride / 3 h / 0 - 20 °C

7.1: silver(l) oxide / N,N-dimethyl-formamide / 14 h / 20 °C

8.1: sulfuric acid; water / 1,4-dioxane / 3 h / 20 °C / Heating / reflux

9.1: dipyridinium dichromate / dichloromethane / 10 h / 0 - 20 °C / Molecular sieve

10.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 70 °C

11.1: triphenylphosphine / methanol; water / 17 h

12.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

With 2-hydroxypyridin; hydrogenchloride; dipyridinium dichromate; di-isopropyl azodicarboxylate; sulfuric acid; water; tri-n-butyl-tin hydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; silver(l) oxide; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene;