(S)-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[2,2-dimethyl-3-(triphenylmethylamino)propyl]amino-2-(2-nitrobenzenesulfonyl)aminopropane-1-ol

Base Information

• Chemical Name: (S)-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[2,2-dimethyl-3-(triphenylmethylamino)propyl]amino-2-(2-nitrobenzenesulfonyl)aminopropane-1-ol
• CAS No.: 1221817-46-4
• Molecular Formula: C₄₉H₄₂F₁₂N₄O₅S
• Molecular Weight: 1026.94

Synonyms:(S)-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[2,2-dimethyl-3-(triphenylmethylamino)propyl]amino-2-(2-nitrobenzenesulfonyl)aminopropane-1-ol

Chemical Property of (S)-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[2,2-dimethyl-3-(triphenylmethylamino)propyl]amino-2-(2-nitrobenzenesulfonyl)aminopropane-1-ol

Chemical Property:

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Technology Process of (S)-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[2,2-dimethyl-3-(triphenylmethylamino)propyl]amino-2-(2-nitrobenzenesulfonyl)aminopropane-1-ol

There total 1 articles about (S)-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[2,2-dimethyl-3-(triphenylmethylamino)propyl]amino-2-(2-nitrobenzenesulfonyl)aminopropane-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2,2-dimethyl-N-(triphenylmethyl)propane-1,3-diamine (1221817-42-0) + (S)-bis[3,5-bis(trifluoromethyl)phenyl][1-(2-nitrobenzenesulfonyl)aziridine-2-yl]methanol (1221817-40-8) → (S)-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[2,2-dimethyl-3-(triphenylmethylamino)propyl]amino-2-(2-nitrobenzenesulfonyl)aminopropane-1-ol (1221817-46-4)

Guidance literature:

With triethylamine; In acetonitrile; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ja101216x

Reference yield: 77.0%

(S)-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[2,2-dimethyl-3-(triphenylmethylamino)propyl]amino-2-(2-nitrobenzenesulfonyl)aminopropane-1-ol (1221817-46-4) → (S)-2-amino-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[2,2-dimethyl-3-(triphenylmethylamino)propyl]amino-propane-1-ol (1221817-51-1)

Guidance literature:

With thiophenol; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; Inert atmosphere;

DOI:10.1021/ja101216x

upstream raw materials:

2,2-dimethyl-N-(triphenylmethyl)propane-1,3-diamine

(S)-bis[3,5-bis(trifluoromethyl)phenyl][1-(2-nitrobenzenesulfonyl)aziridine-2-yl]methanol

Downstream raw materials:

(S)-2-amino-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[2,2-dimethyl-3-(triphenylmethylamino)propyl]amino-propane-1-ol

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