{6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-yl}-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:{6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-yl}-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-carbamic acid tert-butyl ester
CAS No.:405939-77-7
Molecular Formula:C₃₃H₄₇ClN₆O₅Si
Molecular Weight:671.312
Hs Code.:

{6'-[<i>tert</i>-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-yl}-[3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-propyl]-carbamic acid <i>tert</i>-butyl ester

Synonyms:{6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-yl}-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-carbamic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of {6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-yl}-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of {6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-yl}-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-carbamic acid tert-butyl ester

There total 5 articles about {6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-yl}-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 405939-20-0
{6'-[(tert-butoxycarbonyl)(3-chlorophenyl)amino][2,2']bipyrazinyl-6-yl}carbamic acid tert-butyl ester

: 89031-84-5
3-(tert-butyldimethylsilyloxy)propyl bromide

: 405939-77-7
{6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-yl}-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 3.5h;
DOI:10.1021/jm040099a

Reference yield:

: 405940-12-7
(3-chlorophenyl)(6-chloropyrazin-2-yl)carbamic acid tert-butyl ester

: 405939-77-7
{6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-yl}-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / Pd(PPh₃)2Cl₂; LiCl / toluene / 6.5 h / 100 °C

2: 96 percent / aq. LiOH / tetrahydrofuran / 2 h / 20 °C

3: 68 percent / diphenylphosphoryl azide; Et₃N / toluene / 3.5 h / 60 - 90 °C

4: 88 percent / Cs₂CO₃ / dimethylformamide / 3.5 h / 70 °C

With bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide; diphenylphosphoranyl azide; caesium carbonate; triethylamine; lithium chloride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 1: Stille coupling / 3: Curtius rearrangement;
DOI:10.1021/jm040099a

Reference yield:

: 405939-76-6
6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-carboxylic acid

: 405939-77-7
{6'-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-[2,2']bipyrazinyl-6-yl}-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / diphenylphosphoryl azide; Et₃N / toluene / 3.5 h / 60 - 90 °C

2: 88 percent / Cs₂CO₃ / dimethylformamide / 3.5 h / 70 °C

With diphenylphosphoranyl azide; caesium carbonate; triethylamine; In N,N-dimethyl-formamide; toluene; 1: Curtius rearrangement;
DOI:10.1021/jm040099a