((2R,3R,5R)-5-(4-amino-2-oxopyrimidine-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl-4-methylbenzenesulfonate

Base Information

Chemical Name:((2R,3R,5R)-5-(4-amino-2-oxopyrimidine-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl-4-methylbenzenesulfonate
CAS No.:1151528-53-8
Molecular Formula:C₁₆H₁₇F₂N₃O₆S
Molecular Weight:417.39
Hs Code.:

Synonyms:((2R,3R,5R)-5-(4-amino-2-oxopyrimidine-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl-4-methylbenzenesulfonate

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((2R,3R,5R)-5-(4-amino-2-oxopyrimidine-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl-4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of ((2R,3R,5R)-5-(4-amino-2-oxopyrimidine-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl-4-methylbenzenesulfonate

There total 9 articles about ((2R,3R,5R)-5-(4-amino-2-oxopyrimidine-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl-4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1151528-38-9
C₃₀H₂₅F₂N₃O₈S

: 1151528-53-8
((2R,3R,5R)-5-(4-amino-2-oxopyrimidine-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl-4-methylbenzenesulfonate

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 3h;

Reference yield:

: 1151528-37-8
C₂₉H₃₃F₂N₃O₆Si

: 1151528-53-8
((2R,3R,5R)-5-(4-amino-2-oxopyrimidine-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl-4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3.5 h / 0 °C

2: pyridine; triethylamine

3: ammonia / methanol

With pyridine; tetrabutyl ammonium fluoride; ammonia; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1016/j.tetlet.2013.11.018

Reference yield:

: 1020657-43-5
N⁴,O-^3’-dibenzoyl-2’,2’-difluoro-2-deoxycytidine

: 1151528-53-8
((2R,3R,5R)-5-(4-amino-2-oxopyrimidine-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl-4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; triethylamine

2: ammonia / methanol

With pyridine; ammonia; triethylamine; In methanol;
DOI:10.1016/j.tetlet.2013.11.018