[2-(di-tert-butoxy-phosphoryloxy)-1-(4-hexyl-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[2-(di-tert-butoxy-phosphoryloxy)-1-(4-hexyl-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester
CAS No.:448959-75-9
Molecular Formula:C₂₈H₄₉N₂O₇P
Molecular Weight:556.68
Hs Code.:

[2-(di-<i>tert</i>-butoxy-phosphoryloxy)-1-(4-hexyl-phenylcarbamoyl)-ethyl]-carbamic acid <i>tert</i>-butyl ester

Synonyms:[2-(di-tert-butoxy-phosphoryloxy)-1-(4-hexyl-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

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Chemical Property of [2-(di-tert-butoxy-phosphoryloxy)-1-(4-hexyl-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Chemical Property:

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Technology Process of [2-(di-tert-butoxy-phosphoryloxy)-1-(4-hexyl-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

There total 6 articles about [2-(di-tert-butoxy-phosphoryloxy)-1-(4-hexyl-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 137348-86-8
di-tert-butyl diisopropylphosphoramide

: 448959-71-5
[1-(4-hexyl-phenylcarbamoyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

: 448959-75-9
[2-(di-tert-butoxy-phosphoryloxy)-1-(4-hexyl-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: di-tert-butyl diisopropylphosphoramide; [1-(4-hexyl-phenylcarbamoyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester; With 1H-tetrazole;

With dihydrogen peroxide;

Reference yield:

: 33228-45-4
4-hexylaniline

: 448959-75-9
[2-(di-tert-butoxy-phosphoryloxy)-1-(4-hexyl-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: PyBOP; DIEA / CH₂Cl₂ / 6 h / 20 °C

2: H₂ / Pd/C / ethanol / 12 h / 20 °C

3: tetrazole / tetrahydrofuran; CH₂Cl₂ / 12 h / 20 °C

4: aq. H₂O₂ / 4 h / 20 °C

With 1H-tetrazole; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(03)00812-6

Reference yield:

: 47173-80-8
N-Boc-D-serine(Bzl)-OH

: 448959-75-9
[2-(di-tert-butoxy-phosphoryloxy)-1-(4-hexyl-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: PyBOP; DIEA / CH₂Cl₂ / 6 h / 20 °C

2: H₂ / Pd/C / ethanol / 12 h / 20 °C

3: tetrazole / tetrahydrofuran; CH₂Cl₂ / 12 h / 20 °C

4: aq. H₂O₂ / 4 h / 20 °C

With 1H-tetrazole; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(03)00812-6