N-{12-[3-(bis-pyridin-2-ylmethyl-carbamoyl)-propionylamino]-dodecyl}-succinamic acid 2,2-diphenyl-ethyl ester

Base Information

• Chemical Name: N-{12-[3-(bis-pyridin-2-ylmethyl-carbamoyl)-propionylamino]-dodecyl}-succinamic acid 2,2-diphenyl-ethyl ester
• CAS No.: 884592-16-9
• Molecular Formula: C₄₆H₅₉N₅O₅
• Molecular Weight: 762.005

Synonyms:N-{12-[3-(bis-pyridin-2-ylmethyl-carbamoyl)-propionylamino]-dodecyl}-succinamic acid 2,2-diphenyl-ethyl ester

Chemical Property of N-{12-[3-(bis-pyridin-2-ylmethyl-carbamoyl)-propionylamino]-dodecyl}-succinamic acid 2,2-diphenyl-ethyl ester

Chemical Property:

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Technology Process of N-{12-[3-(bis-pyridin-2-ylmethyl-carbamoyl)-propionylamino]-dodecyl}-succinamic acid 2,2-diphenyl-ethyl ester

There total 2 articles about N-{12-[3-(bis-pyridin-2-ylmethyl-carbamoyl)-propionylamino]-dodecyl}-succinamic acid 2,2-diphenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-{12-[3-(2,2-diphenyl-ethoxycarbonyl)-propionylamino]-dodecyl}-succinamic acid + bis[(2-pyridyl)methyl]amine (1539-42-0) → N-{12-[3-(bis-pyridin-2-ylmethyl-carbamoyl)-propionylamino]-dodecyl}-succinamic acid 2,2-diphenyl-ethyl ester (884592-16-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 14h;

DOI:10.1002/anie.200502624

Reference yield:

2,2-diphenylethyl 4-(12-aminododecylamino)-4-oxobutanoate (900524-88-1) → N-{12-[3-(bis-pyridin-2-ylmethyl-carbamoyl)-propionylamino]-dodecyl}-succinamic acid 2,2-diphenyl-ethyl ester (884592-16-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 - 60 °C

2: EDCI; DMAP / CH₂Cl₂ / 14 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;

DOI:10.1002/anie.200502624

Reference yield: 42.0%

N-{12-[3-(bis-pyridin-2-ylmethyl-carbamoyl)-propionylamino]-dodecyl}-succinamic acid 2,2-diphenyl-ethyl ester (884592-16-9) + p-xylylidenediamine (539-48-0) + benzene-1,3-dicarbonyl dichloride (99-63-8) → (C5H4NCH2)2NCOCH2CH2CONH(CH2)12NHCOCH2CH2COOCH2CH(C6H5)2*(C6H4CH2NHCOC6H4CONHCH2C6H4CH2NHCOC6H4CONHCH2) (884592-17-0)

Guidance literature:

With triethylamine; In chloroform;

DOI:10.1002/anie.200502624

upstream raw materials:

bis[(2-pyridyl)methyl]amine

2,2-diphenylethyl 4-(12-aminododecylamino)-4-oxobutanoate

Downstream raw materials:

(C₅H₄NCH₂)2NCOCH₂CH₂CONH(CH₂)12NHCOCH₂CH₂COOCH₂CH(C₆H₅)2*(C₆H₄CH₂NHCOC₆H₄CONHCH₂C₆H₄CH₂NHCOC₆H₄CONHCH₂)

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