2-(trimethylsilyl)ethyl 1-(3-methoxy-3-oxopropyl)-2-oxocyclohexane-1-carboxylate

Base Information

Chemical Name:2-(trimethylsilyl)ethyl 1-(3-methoxy-3-oxopropyl)-2-oxocyclohexane-1-carboxylate
CAS No.:1596247-65-2
Molecular Formula:C₁₆H₂₈O₅Si
Molecular Weight:328.481
Hs Code.:

Synonyms:2-(trimethylsilyl)ethyl 1-(3-methoxy-3-oxopropyl)-2-oxocyclohexane-1-carboxylate

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Chemical Property of 2-(trimethylsilyl)ethyl 1-(3-methoxy-3-oxopropyl)-2-oxocyclohexane-1-carboxylate

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Technology Process of 2-(trimethylsilyl)ethyl 1-(3-methoxy-3-oxopropyl)-2-oxocyclohexane-1-carboxylate

There total 1 articles about 2-(trimethylsilyl)ethyl 1-(3-methoxy-3-oxopropyl)-2-oxocyclohexane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.2%

: 20160-60-5
2-(trimethylsilyl)-ethoxycarbonyl chloride

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 1596247-65-2
2-(trimethylsilyl)ethyl 1-(3-methoxy-3-oxopropyl)-2-oxocyclohexane-1-carboxylate

Guidance literature:: cyclohexanone; With lithium hexamethyldisilazane; In tetrahydrofuran; at 23 ℃; Inert atmosphere; Cooling with acetone-dry ice;

2-(trimethylsilyl)-ethoxycarbonyl chloride; In tetrahydrofuran; at 23 ℃; Inert atmosphere; Cooling with acetone-dry ice;

acrylic acid methyl ester; In tetrahydrofuran; at 23 ℃; Cooling with ice; Inert atmosphere;
DOI:10.1021/ol500355z

Reference yield:

: 35466-83-2
allyl methyl carbonate

: 1596247-65-2
2-(trimethylsilyl)ethyl 1-(3-methoxy-3-oxopropyl)-2-oxocyclohexane-1-carboxylate

: C₁₃H₂₀O₃

: 288301-41-7
(+)-methyl 3-[(1R)-2-oxo-1-(2-propenyl)cyclohexyl]propanoate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (S)-4-tert-butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazol; tetrabutylammonium triphenyldifluorosilicate; In tetrahydrofuran; at 25 ℃; Overall yield = 93 %; Optical yield = 89 %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol500355z