1,4-bis[2-({4-[(triisopropylsilyl)ethynyl]pyridin-3-yl}ethynyl)phenyl]buta-1,3-diyne

Base Information

Chemical Name:1,4-bis[2-({4-[(triisopropylsilyl)ethynyl]pyridin-3-yl}ethynyl)phenyl]buta-1,3-diyne
CAS No.:1026707-45-8
Molecular Formula:C₅₂H₅₆N₂Si₂
Molecular Weight:765.201
Hs Code.:

Synonyms:1,4-bis[2-({4-[(triisopropylsilyl)ethynyl]pyridin-3-yl}ethynyl)phenyl]buta-1,3-diyne

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Chemical Property of 1,4-bis[2-({4-[(triisopropylsilyl)ethynyl]pyridin-3-yl}ethynyl)phenyl]buta-1,3-diyne

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Technology Process of 1,4-bis[2-({4-[(triisopropylsilyl)ethynyl]pyridin-3-yl}ethynyl)phenyl]buta-1,3-diyne

There total 8 articles about 1,4-bis[2-({4-[(triisopropylsilyl)ethynyl]pyridin-3-yl}ethynyl)phenyl]buta-1,3-diyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 860022-00-0
1-(2-ethynylphenyl)-2-[4-(triisopropylsilylethynyl)pyridin-3-yl]ethyne

: 1026707-45-8
1,4-bis[2-({4-[(triisopropylsilyl)ethynyl]pyridin-3-yl}ethynyl)phenyl]buta-1,3-diyne

Guidance literature:: With pyridine; oxygen; copper(l) chloride; at 20 ℃; for 48h;
DOI:10.1021/jo040276f

Reference yield:

: 860021-82-5
3-bromo-4-(triisopropylsilylethynyl)pyridine

: 1026707-45-8
1,4-bis[2-({4-[(triisopropylsilyl)ethynyl]pyridin-3-yl}ethynyl)phenyl]buta-1,3-diyne

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / hexane; diethyl ether / 1.5 h / -78 °C

1.2: 80 percent / 1,2-diiodoethane / hexane; diethyl ether / 3 h / -78 °C

2.1: 96 percent / CuI; triethylamine; PdCl₂(PPh₃)2 / 20 °C

3.1: 99 percent / K₂CO₃ / methanol / 20 h / 20 °C

4.1: 77 percent / CuI; triethylamine / PdCl₂(PPh₃)2 / toluene / 144 h / 20 °C

5.1: 88 percent / K₂CO₃ / methanol / 1.5 h / 20 °C

6.1: 94 percent / CuCl; O₂; pyridine / 48 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; oxygen; potassium carbonate; triethylamine; copper(l) chloride; bis-triphenylphosphine-palladium(II) chloride; In methanol; diethyl ether; hexane; toluene; 2.1: Sonogashira reaction / 4.1: Sonogashira coupling / 6.1: Hay homocoupling;
DOI:10.1021/jo040276f

Reference yield:

: 860021-85-8
3-ethynyl-4-triisopropylsilylethynylpyridine

: 1026707-45-8
1,4-bis[2-({4-[(triisopropylsilyl)ethynyl]pyridin-3-yl}ethynyl)phenyl]buta-1,3-diyne

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / CuI; triethylamine / PdCl₂(PPh₃)2 / toluene / 144 h / 20 °C

2: 88 percent / K₂CO₃ / methanol / 1.5 h / 20 °C

3: 94 percent / CuCl; O₂; pyridine / 48 h / 20 °C

With pyridine; copper(l) iodide; oxygen; potassium carbonate; triethylamine; copper(l) chloride; bis-triphenylphosphine-palladium(II) chloride; In methanol; toluene; 1: Sonogashira coupling / 3: Hay homocoupling;
DOI:10.1021/jo040276f