5-[4-(4-chloropyridin-3-yl)benzyl]-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

Base Information

Chemical Name:5-[4-(4-chloropyridin-3-yl)benzyl]-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline
CAS No.:1030137-90-6
Molecular Formula:C₂₂H₁₉ClN₂O₂
Molecular Weight:378.858
Hs Code.:

Synonyms:5-[4-(4-chloropyridin-3-yl)benzyl]-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

Suppliers and Price of 5-[4-(4-chloropyridin-3-yl)benzyl]-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[4-(4-chloropyridin-3-yl)benzyl]-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-[4-(4-chloropyridin-3-yl)benzyl]-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

There total 9 articles about 5-[4-(4-chloropyridin-3-yl)benzyl]-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-[4-(4-chloropyridin-3-yl)benzyl]-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline trifluoroacetate

: 1030137-90-6
5-[4-(4-chloropyridin-3-yl)benzyl]-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

Guidance literature:: 5-[4-(4-chloropyridin-3-yl)benzyl]-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline trifluoroacetate; With hydrogenchloride; In water;

With sodium hydroxide; In water;

Reference yield:

: 180798-19-0
5-(4-bromobenzyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline

: 1030137-90-6
5-[4-(4-chloropyridin-3-yl)benzyl]-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / methanol / 20 °C

1.2: 20 °C

2.1: sodium hydroxide / dichloromethane; water / 2 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran; water / 0 - 20 °C

4.1: sodium carbonate / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 16 h / Heating / reflux

5.1: dichloromethane / 2 h / 0 - 20 °C

6.1: hydrogenchloride / water

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; sodium carbonate; palladium diacetate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 4.1: Suzuki Coupling;

Reference yield:

: 1029806-32-3
5-(4-bromobenzyl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

: 1030137-90-6
5-[4-(4-chloropyridin-3-yl)benzyl]-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / tetrahydrofuran; water / 0 - 20 °C

2: sodium carbonate / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 16 h / Heating / reflux

3: dichloromethane / 2 h / 0 - 20 °C

4: hydrogenchloride / water

With hydrogenchloride; sodium hydroxide; sodium carbonate; palladium diacetate; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 2: Suzuki Coupling;