3-(4-aminophenyl)-5-({[(3-morpholin-4-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide

Base Information

Chemical Name:3-(4-aminophenyl)-5-({[(3-morpholin-4-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide
CAS No.:1446246-71-4
Molecular Formula:C₁₈H₂₄N₆O₃S
Molecular Weight:404.493
Hs Code.:

Synonyms:3-(4-aminophenyl)-5-({[(3-morpholin-4-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide

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Chemical Property of 3-(4-aminophenyl)-5-({[(3-morpholin-4-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide

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Technology Process of 3-(4-aminophenyl)-5-({[(3-morpholin-4-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide

There total 9 articles about 3-(4-aminophenyl)-5-({[(3-morpholin-4-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1446246-70-3
5-({[(3-morpholin-4-ylpropyl)amino]carbonyl}amino)-3-(4-nitrophenyl)isothiazol-4-carboxamide

: 1446246-71-4
3-(4-aminophenyl)-5-({[(3-morpholin-4-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide

Guidance literature:: With platinum(II) oxide; hydrogen; In methanol; for 16.5h; under 3102.97 Torr;

Reference yield:

: 909028-96-2
3-amino-3-(4-nitrophenyl)-2-thioformamidoacrylonitrile

: 1446246-71-4
3-(4-aminophenyl)-5-({[(3-morpholin-4-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dihydrogen peroxide / ethanol / 22 h / Inert atmosphere

2.1: dmap; N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 22.01 h / 20 °C

3.1: 1,4-dioxane / 2 h / 80 °C

4.1: sulfuric acid / 1.5 h / 45 °C

4.2: Cooling with ice

5.1: platinum(II) oxide; hydrogen / methanol / 16.5 h / 3102.97 Torr

With dmap; platinum(II) oxide; sulfuric acid; hydrogen; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethanol; 1,2-dichloro-ethane;

Reference yield:

: 605661-26-5
2-[amino(4-nitrophenyl)methylene]malononitrile

: 1446246-71-4
3-(4-aminophenyl)-5-({[(3-morpholin-4-ylpropyl)amino]carbonyl}amino)isothiazol-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: O,O-Diethyl hydrogen phosphorodithioate / ethanol; water / 100 °C / Inert atmosphere

2.1: dihydrogen peroxide / ethanol / 22 h / Inert atmosphere

3.1: dmap; N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 22.01 h / 20 °C

4.1: 1,4-dioxane / 2 h / 80 °C

5.1: sulfuric acid / 1.5 h / 45 °C

5.2: Cooling with ice

6.1: platinum(II) oxide; hydrogen / methanol / 16.5 h / 3102.97 Torr

With dmap; platinum(II) oxide; sulfuric acid; hydrogen; dihydrogen peroxide; O,O-Diethyl hydrogen phosphorodithioate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethanol; water; 1,2-dichloro-ethane;