3,5-dichlorobenzyl 4-( 4-(1H-1,2,3-triazol-4-yl)butanamido )piperidine-1-carboxylate

Base Information

Chemical Name:3,5-dichlorobenzyl 4-( 4-(1H-1,2,3-triazol-4-yl)butanamido )piperidine-1-carboxylate
CAS No.:1613513-14-6
Molecular Formula:C₁₉H₂₃Cl₂N₅O₃
Molecular Weight:440.329
Hs Code.:

Synonyms:3,5-dichlorobenzyl 4-( 4-(1H-1,2,3-triazol-4-yl)butanamido )piperidine-1-carboxylate

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Chemical Property of 3,5-dichlorobenzyl 4-( 4-(1H-1,2,3-triazol-4-yl)butanamido )piperidine-1-carboxylate

Chemical Property:

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Technology Process of 3,5-dichlorobenzyl 4-( 4-(1H-1,2,3-triazol-4-yl)butanamido )piperidine-1-carboxylate

There total 6 articles about 3,5-dichlorobenzyl 4-( 4-(1H-1,2,3-triazol-4-yl)butanamido )piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 4-(1H-1,2,3-triazol-4-yl)butanoic acid

: 1246639-95-1
3,5-dichlorobenzyl-4-aminopiperidine-1-carboxylate hydrochloride

: 1613513-14-6
3,5-dichlorobenzyl 4-( 4-(1H-1,2,3-triazol-4-yl)butanamido )piperidine-1-carboxylate

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1016/j.bmcl.2018.05.030

Reference yield:

: 53293-00-8
hex-5-ynoic acid

: 1613513-14-6
3,5-dichlorobenzyl 4-( 4-(1H-1,2,3-triazol-4-yl)butanamido )piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium chloride / ethyl acetate; water; tert-butyl alcohol

2: ethanol

3: N,N-dimethyl-formamide; ethyl acetate; diethyl ether

With sodium chloride; In diethyl ether; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1175526-48-3
3,5-dichlorobenzyl carbonochloridate

: 1613513-14-6
3,5-dichlorobenzyl 4-( 4-(1H-1,2,3-triazol-4-yl)butanamido )piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / dichloromethane / 20 °C

2: hydrogenchloride / dichloromethane; 1,4-dioxane

3: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 48 h / 20 °C

With hydrogenchloride; sodium hydrogencarbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2018.05.030