N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-2,4-dichlorobenzamide

Base Information

Chemical Name:N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-2,4-dichlorobenzamide
CAS No.:168078-44-2
Molecular Formula:C₂₆H₁₉Cl₂N₃O₂
Molecular Weight:476.362
Hs Code.:

Synonyms:N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-2,4-dichlorobenzamide

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Chemical Property of N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-2,4-dichlorobenzamide

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Technology Process of N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-2,4-dichlorobenzamide

There total 9 articles about N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-2,4-dichlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89-75-8
2,4-dichlorobenzoyl chloride

: 168078-59-9
10,11-dihydro-10-(4-aminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

: 168078-44-2
N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-2,4-dichlorobenzamide

Guidance literature:: DOI:10.1021/jm980179c

Reference yield:

: 168078-58-8
10,11-dihydro-10(4-nitrobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

: 168078-44-2
N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-2,4-dichlorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10 percent Pd/C / methanol

2: Et₃N / CH₂Cl₂

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/S0960-894X(03)00388-3

Reference yield:

: 22162-53-4
10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine

: 168078-44-2
N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-2,4-dichlorobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂

2: H₂ / 10 percent Pd/C / methanol

3: Et₃N / CH₂Cl₂

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/S0960-894X(03)00388-3