2-(1-cyclohexylmethyl-7-methoxy-1H-indol-3-yl)-5-ethyl-thiazole-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2-(1-cyclohexylmethyl-7-methoxy-1H-indol-3-yl)-5-ethyl-thiazole-4-carboxylic acid ethyl ester
• CAS No.: 865712-64-7
• Molecular Formula: C₂₄H₃₀N₂O₃S
• Molecular Weight: 426.58
• Mol file: 865712-64-7.mol

Synonyms:2-(1-cyclohexylmethyl-7-methoxy-1H-indol-3-yl)-5-ethyl-thiazole-4-carboxylic acid ethyl ester

Chemical Property of 2-(1-cyclohexylmethyl-7-methoxy-1H-indol-3-yl)-5-ethyl-thiazole-4-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(1-cyclohexylmethyl-7-methoxy-1H-indol-3-yl)-5-ethyl-thiazole-4-carboxylic acid ethyl ester

There total 1 articles about 2-(1-cyclohexylmethyl-7-methoxy-1H-indol-3-yl)-5-ethyl-thiazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(cyclohexyl)methyl-7-methoxy-1H-indole-3-carbothioic acid amide (865712-60-3) + ethyl 3-chloro-2-oxopentanoate (50774-87-3) → 2-(1-cyclohexylmethyl-7-methoxy-1H-indol-3-yl)-5-ethyl-thiazole-4-carboxylic acid ethyl ester (865712-64-7)

Guidance literature:

In DMF (N,N-dimethyl-formamide); at 140 ℃; for 0.416667h; Irradiation;

Reference yield:

2-(1-cyclohexylmethyl-7-methoxy-1H-indol-3-yl)-5-ethyl-thiazole-4-carboxylic acid ethyl ester (865712-64-7) → [2-(1-cyclohexylmethyl-7-methoxy-1H-indol-3-yl)-5-ethyl-thiazole-4-yl]-methanol (865712-65-8)

Guidance literature:

2-(1-cyclohexylmethyl-7-methoxy-1H-indol-3-yl)-5-ethyl-thiazole-4-carboxylic acid ethyl ester; With lithium borohydride; In tetrahydrofuran; at 0 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water;

upstream raw materials:

1-(cyclohexyl)methyl-7-methoxy-1H-indole-3-carbothioic acid amide

ethyl 3-chloro-2-oxopentanoate

Downstream raw materials:

[2-(1-cyclohexylmethyl-7-methoxy-1H-indol-3-yl)-5-ethyl-thiazole-4-yl]-methanol