3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-(pyridin-4-yl)propanoic acid

Base Information

Chemical Name:3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-(pyridin-4-yl)propanoic acid
CAS No.:1025762-83-7
Molecular Formula:C₂₃H₂₀FN₃O₂
Molecular Weight:389.429
Hs Code.:

Synonyms:3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-(pyridin-4-yl)propanoic acid

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Chemical Property of 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-(pyridin-4-yl)propanoic acid

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Technology Process of 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-(pyridin-4-yl)propanoic acid

There total 4 articles about 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-(pyridin-4-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025762-81-5
methyl 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-(pyridin-4-yl)propanoate

: 1025762-83-7
3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-(pyridin-4-yl)propanoic acid

Guidance literature:: With methanol; sodium hydroxide; water; In dimethyl sulfoxide; at 100 ℃;

Reference yield:

: 352-34-1
4-fluoro-1-iodobenzene

: C₁₇H₁₇N₃O₂

: 1025762-83-7
3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-(pyridin-4-yl)propanoic acid

Guidance literature:: With potassium phosphate; copper(l) iodide; In 1,4-dioxane; at 110 ℃; for 24h;
DOI:10.1016/j.bmcl.2013.06.089

Reference yield:

: 1456540-32-1
C₁₃H₁₁N₃O

: 1025762-83-7
3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-(pyridin-4-yl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: titanium tetrachloride / dichloromethane / 12 h / 0 °C

2: sodium hydroxide / methanol; dimethyl sulfoxide / 12 h / 100 °C

3: copper(l) iodide; potassium phosphate / 1,4-dioxane / 24 h / 110 °C

With potassium phosphate; copper(l) iodide; titanium tetrachloride; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; 1: |Mukaiyama Aldol Addition / 3: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2013.06.089