(S)-1-(2-aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride

Base Information

Chemical Name:(S)-1-(2-aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride
CAS No.:1448440-51-4
Molecular Formula:C₇H₉F₂N₃O*ClH
Molecular Weight:225.626
Hs Code.:

Synonyms:(S)-1-(2-aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride

Suppliers and Price of (S)-1-(2-aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 22 raw suppliers

Chemical Property of (S)-1-(2-aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-1-(2-aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride

There total 11 articles about (S)-1-(2-aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1448440-50-3
tert-butyl (S)-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate

: 1448440-51-4
(S)-1-(2-aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; acetonitrile; at 0 - 20 ℃; for 16h;

Reference yield:

: 1448440-40-1
(S)-1-(2-aminoacetyl)-4,4-difluoropyrrolidin-2-carbonitrile 2,2,2-trifluoroacetate

: 1448440-51-4
(S)-1-(2-aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; at 0 ℃; for 0.5h;

Reference yield:

: 102195-80-2
(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

: 1448440-51-4
(S)-1-(2-aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: diethylamino-sulfur trifluoride; ethanol / dichloromethane / 18 h / 20 °C / Inert atmosphere

2.1: potassium hydroxide

3.1: dicyclohexyl-carbodiimide; 1-hydroxy-pyrrolidine-2,5-dione / dichloromethane / 15 - 20 °C

3.2: 0.33 h / 20 °C

4.1: dichloromethane / 1 h

5.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 0.25 h

5.2: 3 h

6.1: pyridine; trifluoroacetic anhydride / dichloromethane; tetrahydrofuran / -15 - 20 °C

7.1: acetonitrile / 0 °C

7.2: 0.5 h / 0 °C

8.1: hydrogenchloride / diethyl ether / 0.5 h / 0 °C

With pyridine; hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; ethanol; diethylamino-sulfur trifluoride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; HATU; trifluoroacetic anhydride; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;