C₆₀H₇₉Cl₂N₃O₁₇Si₂

Base Information

• Chemical Name: C₆₀H₇₉Cl₂N₃O₁₇Si₂
• CAS No.: 159379-86-9
• Molecular Formula: C₆₀H₇₉Cl₂N₃O₁₇Si₂
• Molecular Weight: 1241.37
• Mol file: 159379-86-9.mol

Synonyms:C₆₀H₇₉Cl₂N₃O₁₇Si₂

Chemical Property of C₆₀H₇₉Cl₂N₃O₁₇Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₀H₇₉Cl₂N₃O₁₇Si₂

There total 16 articles about C₆₀H₇₉Cl₂N₃O₁₇Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

C60H81Cl2N3O16Si2 → C60H79Cl2N3O17Si2 (159379-86-9)

Guidance literature:

With dipyridinium dichromate; In N,N-dimethyl-formamide; for 10h; Ambient temperature;

DOI:10.1016/S0040-4039(00)73316-8

Reference yield:

2,6-dibromo-1,4-benzoquinone (19643-45-9) → C60H79Cl2N3O17Si2 (159379-86-9)

Guidance literature:

Multi-step reaction with 15 steps

1: 1.) K₂CO₃ / 1.) DMF, room t., 24 h, 2.) DMF, 0 deg C, 15 min

2: 53 percent / dimethylformamide / 0.5 h / 0 °C

3: 100 percent / Na₂S₂O₄ / CHCl₃; H₂O / 0.5 h / Ambient temperature

4: 80 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

5: 90 percent / K₂CO₃ / acetone / 2 h / 50 °C

6: 80 percent / Bu₄NF / tetrahydrofuran / 0.17 h / 0 °C

7: 85 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

8: 85 percent / LiCl, Pd(Ph₃P)4 / 2,6-di-t-butyl-4-methylphenol / dioxane / 1 h / 90 °C

9: 90 percent / dihydroquinine-9-O-phenanthryl ether, OsO₄, K₂CO₃, K₃ / 2-methyl-propan-2-ol; H₂O / 30 h / Ambient temperature

10: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

11: 90 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

12: 65 percent / NaN₃ / dimethylformamide / 1 h / 50 °C

13: 70 percent / H₂ / PtO₂ / ethyl acetate / 14 h / Ambient temperature

14: 65 percent / Bu₄NF / tetrahydrofuran / 0.5 h / 0 °C

15: 60 percent / PDC / dimethylformamide / 10 h / Ambient temperature

With pyridine; osmium(VIII) oxide; dipyridinium dichromate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; sodium dithionite; dihydroquinidine 0-O-(9'-phenanthryl) ether; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; lithium chloride; potassium hexacyanoferrate(III); platinum(IV) oxide; 2,6-di-tert-butyl-4-methyl-phenol; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water; ethyl acetate; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;

DOI:10.1016/S0040-4039(00)73316-8

Reference yield:

(2S,3R)-methyl 2-phthalimido-3-(tbutyldimethylsilyloxy)-3-(3'-chloro-4'-hydroxy phenyl)propionate (159379-70-1) → C60H79Cl2N3O17Si2 (159379-86-9)

Guidance literature:

Multi-step reaction with 15 steps

1: 1.) K₂CO₃ / 1.) DMF, room t., 24 h, 2.) DMF, 0 deg C, 15 min

2: 53 percent / dimethylformamide / 0.5 h / 0 °C

3: 100 percent / Na₂S₂O₄ / CHCl₃; H₂O / 0.5 h / Ambient temperature

4: 80 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

5: 90 percent / K₂CO₃ / acetone / 2 h / 50 °C

6: 80 percent / Bu₄NF / tetrahydrofuran / 0.17 h / 0 °C

7: 85 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

8: 85 percent / LiCl, Pd(Ph₃P)4 / 2,6-di-t-butyl-4-methylphenol / dioxane / 1 h / 90 °C

9: 90 percent / dihydroquinine-9-O-phenanthryl ether, OsO₄, K₂CO₃, K₃ / 2-methyl-propan-2-ol; H₂O / 30 h / Ambient temperature

10: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

11: 90 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

12: 65 percent / NaN₃ / dimethylformamide / 1 h / 50 °C

13: 70 percent / H₂ / PtO₂ / ethyl acetate / 14 h / Ambient temperature

14: 65 percent / Bu₄NF / tetrahydrofuran / 0.5 h / 0 °C

15: 60 percent / PDC / dimethylformamide / 10 h / Ambient temperature

With pyridine; osmium(VIII) oxide; dipyridinium dichromate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; sodium dithionite; dihydroquinidine 0-O-(9'-phenanthryl) ether; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; lithium chloride; potassium hexacyanoferrate(III); platinum(IV) oxide; 2,6-di-tert-butyl-4-methyl-phenol; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water; ethyl acetate; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;

DOI:10.1016/S0040-4039(00)73316-8

upstream raw materials:

2,6-dibromo-1,4-benzoquinone

(2S,3R)-methyl 2-phthalimido-3-(^tbutyldimethylsilyloxy)-3-(3'-chloro-4'-hydroxy phenyl)propionate

(2S,3R)-3-[4-(5-Bromo-3,6-dioxo-cyclohexa-1,4-dienyloxy)-3-chloro-phenyl]-3-(tert-butyl-dimethyl-silanyloxy)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionic acid methyl ester

C₅₂H₆₄Cl₂N₂O₁₄Si₂