methyl 4-{2-[3,5-dichloro-2-oxo-6-{2-[(2S)-2-propylpyrrolidin-1-yl]ethyl}pyridin-1(2H)-yl]ethyl}benzoate

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Chemical Name:methyl 4-{2-[3,5-dichloro-2-oxo-6-{2-[(2S)-2-propylpyrrolidin-1-yl]ethyl}pyridin-1(2H)-yl]ethyl}benzoate
CAS No.:1201818-52-1
Molecular Formula:C₂₄H₃₀Cl₂N₂O₃
Molecular Weight:465.42
Hs Code.:

Synonyms:methyl 4-{2-[3,5-dichloro-2-oxo-6-{2-[(2S)-2-propylpyrrolidin-1-yl]ethyl}pyridin-1(2H)-yl]ethyl}benzoate

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Chemical Property of methyl 4-{2-[3,5-dichloro-2-oxo-6-{2-[(2S)-2-propylpyrrolidin-1-yl]ethyl}pyridin-1(2H)-yl]ethyl}benzoate

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Technology Process of methyl 4-{2-[3,5-dichloro-2-oxo-6-{2-[(2S)-2-propylpyrrolidin-1-yl]ethyl}pyridin-1(2H)-yl]ethyl}benzoate

There total 4 articles about methyl 4-{2-[3,5-dichloro-2-oxo-6-{2-[(2S)-2-propylpyrrolidin-1-yl]ethyl}pyridin-1(2H)-yl]ethyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S)-2-propylpyrrolidine hydrochloride

: 1201823-19-9
methyl 4-{2-[3,5-dichloro-2-oxo-6-(2-oxoethyl)pyridin-1(2H)-yl]ethyl}benzoate

: 1201818-52-1
methyl 4-{2-[3,5-dichloro-2-oxo-6-{2-[(2S)-2-propylpyrrolidin-1-yl]ethyl}pyridin-1(2H)-yl]ethyl}benzoate

Guidance literature:: (2S)-2-propylpyrrolidine hydrochloride; methyl 4-{2-[3,5-dichloro-2-oxo-6-(2-oxoethyl)pyridin-1(2H)-yl]ethyl}benzoate; With sodium acetate; sodium tris(acetoxy)borohydride; In chloroform; at 20 ℃; for 1h;

With water; sodium hydrogencarbonate; In chloroform;

Reference yield:

: 1091599-63-1
methyl 4-{2-[6-(bromomethyl)-3,5-dichloro-2-oxopyridin-1(2H)-yl]ethyl}benzoate

: 1201818-52-1
methyl 4-{2-[3,5-dichloro-2-oxo-6-{2-[(2S)-2-propylpyrrolidin-1-yl]ethyl}pyridin-1(2H)-yl]ethyl}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: trimethylamine-N-oxide; sodium carbonate / N,N-dimethyl-formamide / 0.25 h / 40 °C

2: potassium tert-butylate / tetrahydrofuran / Cooling with ice

3: formic acid / dichloromethane / 5 h / 70 °C

4: sodium acetate; sodium tris(acetoxy)borohydride / chloroform / 1 h / 20 °C

With formic acid; trimethylamine-N-oxide; potassium tert-butylate; sodium acetate; sodium tris(acetoxy)borohydride; sodium carbonate; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 1091599-79-9
methyl 4-[2-(3,5-dichloro-6-formyl-2-oxopyridin-1(2H)-yl)ethyl]benzoate

: 1201818-52-1
methyl 4-{2-[3,5-dichloro-2-oxo-6-{2-[(2S)-2-propylpyrrolidin-1-yl]ethyl}pyridin-1(2H)-yl]ethyl}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / Cooling with ice

2: formic acid / dichloromethane / 5 h / 70 °C

3: sodium acetate; sodium tris(acetoxy)borohydride / chloroform / 1 h / 20 °C

With formic acid; potassium tert-butylate; sodium acetate; sodium tris(acetoxy)borohydride; In tetrahydrofuran; dichloromethane; chloroform;