C₃₈H₄₈N₂O₆

Base Information

Chemical Name:C₃₈H₄₈N₂O₆
CAS No.:131213-24-6
Molecular Formula:C₃₈H₄₈N₂O₆
Molecular Weight:628.809
Hs Code.:

C<sub>38</sub>H<sub>48</sub>N<sub>2</sub>O<sub>6</sub>

Synonyms:C₃₈H₄₈N₂O₆

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Chemical Property of C₃₈H₄₈N₂O₆

Chemical Property:

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Technology Process of C₃₈H₄₈N₂O₆

There total 14 articles about C₃₈H₄₈N₂O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131196-56-0
[(2R,3R,3aS,5R,5aS,6R,7R,8aR,8bS)-5-(tert-Butyl-dimethyl-silanyloxy)-2-dimethoxymethyl-6-ethyl-7-methyl-dodecahydro-as-indacen-3-yl]-acetaldehyde

: 131213-24-6
C₃₈H₄₈N₂O₆

Guidance literature:: Multi-step reaction with 13 steps

1: 1.) triphenylphosphine / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) 15 min

2: 1.) n-butyllithium / 1.) THF, hexane, from -78 deg C to 25 deg C, 55 min, 2.) from -78 deg C to to 10 deg C, 100 min

3: K₂CO₃ / H₂O; methanol / 4 h / 43 °C

4: tetrahydrofuran / 0.83 h / 25 °C

5: 86 mg / 4-(dimethylamino)pyridine (DMAP) / tetrahydrofuran / 16 h

6: 92 percent / acetone, p-toluenesulfonic acid / 3 h / 25 °C

7: 1.) potassium hexamethyldisilazide / 1.) THF, toluene, a) -78 deg C, 5 min, 0 deg C, 20 min, 2.) a) 0 deg C, 30 min, b) from 0 deg C to 25 deg C, 8 h

8: 71 percent Turnov_. / acetic acid, tetrakis(triphenylphosphine)palladium⁽⁰⁾, triphenylphosphine / tetrahydrofuran / 4 h / 25 °C

9: 94 percent / toluene / 2.5 h / Heating

10: 79 percent / 1.) H₂, 2.) quinoline / 5percent Pd/BaSO₄ / ethyl acetate / 25 °C / 1.) 4 min, 2.) 5 h

11: 85 percent / 48percent hydrofluoric acid / acetonitrile / 0.22 h / 25 °C

12: 36 percent Turnov_. / CH₃OC(O)NSO₂NEt₃ (Burgess reagent) / benzene / 25 - 50 °C

13: 66 percent / t-BuOK / 2-methyl-propan-2-ol / 0.17 h / 25 °C

With quinoline; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Burgess Reagent; hydrogen fluoride; potassium tert-butylate; hydrogen; potassium hexamethylsilazane; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triphenylphosphine; acetone; Pd-BaSO₄; In tetrahydrofuran; methanol; water; ethyl acetate; toluene; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/ja00181a035

Reference yield:

: 123148-46-9
methyl (2R,3R,3aS,5R,5aS,6R,7R,8aR,8bS)-5-(tert-butyldimethylsiloxy)-6-ethyl-2-formyldodecahydro-7-methyl-as-indacene-3-tetrolate 2-(dimethyl acetal)

: 131213-24-6
C₃₈H₄₈N₂O₆

Guidance literature:: Multi-step reaction with 11 steps

1: K₂CO₃ / H₂O; methanol / 4 h / 43 °C

2: tetrahydrofuran / 0.83 h / 25 °C

3: 86 mg / 4-(dimethylamino)pyridine (DMAP) / tetrahydrofuran / 16 h

4: 92 percent / acetone, p-toluenesulfonic acid / 3 h / 25 °C

5: 1.) potassium hexamethyldisilazide / 1.) THF, toluene, a) -78 deg C, 5 min, 0 deg C, 20 min, 2.) a) 0 deg C, 30 min, b) from 0 deg C to 25 deg C, 8 h

6: 71 percent Turnov_. / acetic acid, tetrakis(triphenylphosphine)palladium⁽⁰⁾, triphenylphosphine / tetrahydrofuran / 4 h / 25 °C

7: 94 percent / toluene / 2.5 h / Heating

8: 79 percent / 1.) H₂, 2.) quinoline / 5percent Pd/BaSO₄ / ethyl acetate / 25 °C / 1.) 4 min, 2.) 5 h

9: 85 percent / 48percent hydrofluoric acid / acetonitrile / 0.22 h / 25 °C

10: 36 percent Turnov_. / CH₃OC(O)NSO₂NEt₃ (Burgess reagent) / benzene / 25 - 50 °C

11: 66 percent / t-BuOK / 2-methyl-propan-2-ol / 0.17 h / 25 °C

With quinoline; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Burgess Reagent; hydrogen fluoride; potassium tert-butylate; hydrogen; potassium hexamethylsilazane; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triphenylphosphine; acetone; Pd-BaSO₄; In tetrahydrofuran; methanol; water; ethyl acetate; toluene; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/ja00181a035

Reference yield:

: C₃₇H₅₈O₇SSi

: 131213-24-6
C₃₈H₄₈N₂O₆

Guidance literature:: Multi-step reaction with 9 steps

1: 86 mg / 4-(dimethylamino)pyridine (DMAP) / tetrahydrofuran / 16 h

2: 92 percent / acetone, p-toluenesulfonic acid / 3 h / 25 °C

3: 1.) potassium hexamethyldisilazide / 1.) THF, toluene, a) -78 deg C, 5 min, 0 deg C, 20 min, 2.) a) 0 deg C, 30 min, b) from 0 deg C to 25 deg C, 8 h

4: 71 percent Turnov_. / acetic acid, tetrakis(triphenylphosphine)palladium⁽⁰⁾, triphenylphosphine / tetrahydrofuran / 4 h / 25 °C

5: 94 percent / toluene / 2.5 h / Heating

6: 79 percent / 1.) H₂, 2.) quinoline / 5percent Pd/BaSO₄ / ethyl acetate / 25 °C / 1.) 4 min, 2.) 5 h

7: 85 percent / 48percent hydrofluoric acid / acetonitrile / 0.22 h / 25 °C

8: 36 percent Turnov_. / CH₃OC(O)NSO₂NEt₃ (Burgess reagent) / benzene / 25 - 50 °C

9: 66 percent / t-BuOK / 2-methyl-propan-2-ol / 0.17 h / 25 °C

With quinoline; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Burgess Reagent; hydrogen fluoride; potassium tert-butylate; hydrogen; potassium hexamethylsilazane; toluene-4-sulfonic acid; acetic acid; triphenylphosphine; acetone; Pd-BaSO₄; In tetrahydrofuran; ethyl acetate; toluene; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/ja00181a035