(1R^*,4aS^*,10aS^*)-5-<2',2'-di(4-nitrophenyl)ethoxycarbonyl>-10a-ethoxycarbonyl-1-methoxy-3,10-dioxo-octahydroacridine

Base Information

• Chemical Name: (1R^*,4aS^*,10aS^*)-5-<2',2'-di(4-nitrophenyl)ethoxycarbonyl>-10a-ethoxycarbonyl-1-methoxy-3,10-dioxo-octahydroacridine
• CAS No.: 125836-14-8
• Molecular Formula: C₃₂H₂₉N₃O₁₁
• Molecular Weight: 631.596

Synonyms:(1R^*,4aS^*,10aS^*)-5-<2',2'-di(4-nitrophenyl)ethoxycarbonyl>-10a-ethoxycarbonyl-1-methoxy-3,10-dioxo-octahydroacridine

Chemical Property of (1R^*,4aS^*,10aS^*)-5-<2',2'-di(4-nitrophenyl)ethoxycarbonyl>-10a-ethoxycarbonyl-1-methoxy-3,10-dioxo-octahydroacridine

Chemical Property:

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Technology Process of (1R^*,4aS^*,10aS^*)-5-<2',2'-di(4-nitrophenyl)ethoxycarbonyl>-10a-ethoxycarbonyl-1-methoxy-3,10-dioxo-octahydroacridine

There total 3 articles about (1R^*,4aS^*,10aS^*)-5-<2',2'-di(4-nitrophenyl)ethoxycarbonyl>-10a-ethoxycarbonyl-1-methoxy-3,10-dioxo-octahydroacridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-methoxy-3-<(trimethylsilyl)oxy>01,3-butadiene (59414-23-2) + 3-carboethoxy-1-<2',2'-bis-(4-nitrophenyl)ethoxycarbonyl>-1,4-dihydroquinolin-4-one (125836-09-1) → (1R*,4aS*,10aS*)-5-<2',2'-di(4-nitrophenyl)ethoxycarbonyl>-10a-ethoxycarbonyl-1-methoxy-3,10-dioxo-octahydroacridine (125836-14-8)

Guidance literature:

In toluene; for 18h; Heating;

DOI:10.1016/0040-4020(89)80121-8

Reference yield:

ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate (52980-28-6) → (1R*,4aS*,10aS*)-5-<2',2'-di(4-nitrophenyl)ethoxycarbonyl>-10a-ethoxycarbonyl-1-methoxy-3,10-dioxo-octahydroacridine (125836-14-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / N,N-diisopropylethylamine / CHCl₃ / 20 h / Heating

2: 83 percent / toluene / 18 h / Heating

With N-ethyl-N,N-diisopropylamine; In chloroform; toluene;

DOI:10.1016/0040-4020(89)80121-8

Reference yield:

diethyl (anilinomethylene)malonate (54535-22-7) → (1R*,4aS*,10aS*)-5-<2',2'-di(4-nitrophenyl)ethoxycarbonyl>-10a-ethoxycarbonyl-1-methoxy-3,10-dioxo-octahydroacridine (125836-14-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / 0.5 h / 255 °C

2: 82 percent / N,N-diisopropylethylamine / CHCl₃ / 20 h / Heating

3: 83 percent / toluene / 18 h / Heating

With N-ethyl-N,N-diisopropylamine; In chloroform; toluene;

DOI:10.1016/0040-4020(89)80121-8

upstream raw materials:

1-methoxy-3-<(trimethylsilyl)oxy>01,3-butadiene

3-carboethoxy-1-<2',2'-bis-(4-nitrophenyl)ethoxycarbonyl>-1,4-dihydroquinolin-4-one

diethyl (anilinomethylene)malonate

ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate

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