(1R,2R,3R,4S)-3-(benzyloxy)-5,5-bis[(trityloxy)methyl]cyclohexane-1,2,4-triol

Base Information

Chemical Name:(1R,2R,3R,4S)-3-(benzyloxy)-5,5-bis[(trityloxy)methyl]cyclohexane-1,2,4-triol
CAS No.:691371-40-1
Molecular Formula:C₅₃H₅₀O₆
Molecular Weight:782.976
Hs Code.:

Synonyms:(1R,2R,3R,4S)-3-(benzyloxy)-5,5-bis[(trityloxy)methyl]cyclohexane-1,2,4-triol

Suppliers and Price of (1R,2R,3R,4S)-3-(benzyloxy)-5,5-bis[(trityloxy)methyl]cyclohexane-1,2,4-triol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (1R,2R,3R,4S)-3-(benzyloxy)-5,5-bis[(trityloxy)methyl]cyclohexane-1,2,4-triol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of (1R,2R,3R,4S)-3-(benzyloxy)-5,5-bis[(trityloxy)methyl]cyclohexane-1,2,4-triol

There total 1 articles about (1R,2R,3R,4S)-3-(benzyloxy)-5,5-bis[(trityloxy)methyl]cyclohexane-1,2,4-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 76-83-5
trityl chloride

: 360562-15-8
(1R,2R,3R,4S)-3-(Benzyloxy)-5,5-bis(hydroxymethyl)cyclohexane-1,2,4-triol

: 691371-40-1
(1R,2R,3R,4S)-3-(benzyloxy)-5,5-bis[(trityloxy)methyl]cyclohexane-1,2,4-triol

Guidance literature:: With pyridine; at 100 ℃; for 1h;
DOI:10.1135/cccc20040435

Reference yield: 90.0%

: 691371-40-1
(1R,2R,3R,4S)-3-(benzyloxy)-5,5-bis[(trityloxy)methyl]cyclohexane-1,2,4-triol

: 691371-41-2
(3aS,4R,5S,7aR)-4-(benzyloxy)-2-oxo-6,6-bis[(trityloxy)methyl]hexahydro-2λ⁴-1,3,2-benzodioxathiol-5-ol

Guidance literature:: With thionyl chloride; triethylamine; In diethyl ether; at -75 - -20 ℃; for 4h;
DOI:10.1135/cccc20040435

Reference yield:

: 691371-40-1
(1R,2R,3R,4S)-3-(benzyloxy)-5,5-bis[(trityloxy)methyl]cyclohexane-1,2,4-triol

: 691371-62-7
(1R,2R,3S,6S)-6-[(2-amino-6-chloropyrimidin-4-yl)amino]-4,4-bis(hydroxymethyl)-2-(benzyloxy)cyclohexane-1,3-diol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 90 percent / thionyl chloride; Et₃N / diethyl ether / 4 h / -75 - -20 °C

2.1: pyridine / 20 °C

3.1: 4.95 g / aq. potassium periodate; RuCl₃ / CCl₄; acetonitrile / 1 h / 0 - 20 °C

4.1: LiN₃ / dimethylformamide / 1.5 h / 60 °C

4.2: 68 percent / aq. H₂SO₄ / tetrahydrofuran / 20 °C

5.1: 61 percent / LiAlH₄ / tetrahydrofuran / 2.5 h / Heating

6.1: 68 percent / Et₃N / ethanol / 96 h / 100 °C

7.1: 85 percent / aq. CF₃COOH / 0.25 h / 20 °C

With pyridine; ruthenium trichloride; lithium aluminium tetrahydride; thionyl chloride; lithium azide; potassium metaperiodate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1135/cccc20040435