2-acetylamino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-tritylsulfanyl-propionamide

Base Information

Chemical Name:2-acetylamino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-tritylsulfanyl-propionamide
CAS No.:906666-23-7
Molecular Formula:C₃₂H₃₂N₂O₄S
Molecular Weight:540.683
Hs Code.:

2-acetylamino-<i>N</i>-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-tritylsulfanyl-propionamide

Synonyms:2-acetylamino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-tritylsulfanyl-propionamide

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Chemical Property of 2-acetylamino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-tritylsulfanyl-propionamide

Chemical Property:

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Technology Process of 2-acetylamino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-tritylsulfanyl-propionamide

There total 3 articles about 2-acetylamino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-tritylsulfanyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.5%

: 62-31-7
dopamine hydrochloride

: 27486-87-9
N-acetyl-S-trityl-L-cysteine

: 906666-23-7
2-acetylamino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-tritylsulfanyl-propionamide

Guidance literature:: N-acetyl-S-trityl-L-cysteine; With (2-chloropropyl)dimethylamine hydrochloride; benzotriazol-1-ol; In N,N-dimethyl-formamide; for 2h;

dopamine hydrochloride; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/ol061098a

Reference yield:

: 2799-07-7
S-trityl-L-cysteine

: 906666-23-7
2-acetylamino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-tritylsulfanyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 60.2 percent / sodium hydroxide / H₂O; dioxane / 12 h / 20 °C / pH 9 - 10

2.1: 1-hydroxybenzotriazole; 2-dimethylaminoisopropyl chloride hydrochloride / dimethylformamide / 2 h

2.2: 72.5 percent / potassium carbonate / dimethylformamide / 12 h / 20 °C

With sodium hydroxide; (2-chloropropyl)dimethylamine hydrochloride; benzotriazol-1-ol; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol061098a

Reference yield:

: 76-83-5
trityl chloride

: 906666-23-7
2-acetylamino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-tritylsulfanyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 62.2 percent / dimethylformamide / 48 h / 20 °C

2.1: 60.2 percent / sodium hydroxide / H₂O; dioxane / 12 h / 20 °C / pH 9 - 10

3.1: 1-hydroxybenzotriazole; 2-dimethylaminoisopropyl chloride hydrochloride / dimethylformamide / 2 h

3.2: 72.5 percent / potassium carbonate / dimethylformamide / 12 h / 20 °C

With sodium hydroxide; (2-chloropropyl)dimethylamine hydrochloride; benzotriazol-1-ol; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol061098a