t-butyl-3-endo-phenoxyacetamido-2-oxo-1-azabicyclo<3.2.0>heptane-7-exo-carboxylate

Base Information

Chemical Name:t-butyl-3-endo-phenoxyacetamido-2-oxo-1-azabicyclo<3.2.0>heptane-7-exo-carboxylate
CAS No.:96990-00-0
Molecular Formula:C₁₉H₂₄N₂O₅
Molecular Weight:360.41
Hs Code.:

Synonyms:t-butyl-3-endo-phenoxyacetamido-2-oxo-1-azabicyclo<3.2.0>heptane-7-exo-carboxylate

Suppliers and Price of t-butyl-3-endo-phenoxyacetamido-2-oxo-1-azabicyclo<3.2.0>heptane-7-exo-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of t-butyl-3-endo-phenoxyacetamido-2-oxo-1-azabicyclo<3.2.0>heptane-7-exo-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of t-butyl-3-endo-phenoxyacetamido-2-oxo-1-azabicyclo<3.2.0>heptane-7-exo-carboxylate

There total 14 articles about t-butyl-3-endo-phenoxyacetamido-2-oxo-1-azabicyclo<3.2.0>heptane-7-exo-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 96960-45-1
t-butyl-3-endo-amino-2-oxo-1-azabicyclo<3.2.0>heptane-7-exo-carboxylate

: 122-59-8
2-phenoxyacetic acid

: 96990-00-0
t-butyl-3-endo-phenoxyacetamido-2-oxo-1-azabicyclo<3.2.0>heptane-7-exo-carboxylate

Guidance literature:: With sodium sulfate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane; for 24h;
DOI:10.1016/S0040-4020(01)82070-6

Reference yield:

: 96960-33-7,96960-34-8,121049-94-3,121071-76-9
1-benzyl-2-(carboxylic acid t-butyl ester)-4-(carboxylic acid methyl ester)azetidine

: 96990-00-0
t-butyl-3-endo-phenoxyacetamido-2-oxo-1-azabicyclo<3.2.0>heptane-7-exo-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: NaBH₄ / methanol / 0 °C

2: 1.) H₂, 2.) pyridine / 1.) Pd/C / 1.) MeOH, 50 deg C, 2.) CH₂Cl₂

3: dicyclohexylcarbodi-imide, Me₂SO, pyridine, CF₃COOH / benzene / 0 - 25 °C

4: CH₂Cl₂ / 25 °C

5: H₂ / (Ph₃P)3RhCl / benzene / 50 °C

6: H₂ / 10percent Pd/C / methanol / 0 °C

7: 2,2'-dipyridyl disulphide, PPh₃

8: 47 percent / 1.) LiN(SiMe₃)2, 2.) Ph₂PO-O-NH₂ / tetrahydrofuran / 1.) -78 deg C

9: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / CH₂Cl₂

With pyridine; sodium tetrahydroborate; 2,2'-dipyridyldisulphide; O-(diphenylphosphinyl)hydroxylamine; hydrogen; dimethyl sulfoxide; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; dicyclohexyl-carbodiimide; triphenylphosphine; trifluoroacetic acid; lithium hexamethyldisilazane; palladium on activated charcoal; Wilkinson's catalyst; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1039/c39850000194

Reference yield:

: 96960-39-3,96960-52-0
trans-N-(benzyloxycarbonyl)-2-(carboxylic acid t-butyl ester)-4-(formyl)azetidine

: 96990-00-0
t-butyl-3-endo-phenoxyacetamido-2-oxo-1-azabicyclo<3.2.0>heptane-7-exo-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: CH₂Cl₂ / 25 °C

2: H₂ / (Ph₃P)3RhCl / benzene / 50 °C

3: H₂ / 10percent Pd/C / methanol / 0 °C

4: 2,2'-dipyridyl disulphide, PPh₃

5: 47 percent / 1.) LiN(SiMe₃)2, 2.) Ph₂PO-O-NH₂ / tetrahydrofuran / 1.) -78 deg C

6: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / CH₂Cl₂

With 2,2'-dipyridyldisulphide; O-(diphenylphosphinyl)hydroxylamine; hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triphenylphosphine; lithium hexamethyldisilazane; palladium on activated charcoal; Wilkinson's catalyst; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1039/c39850000194