N-(5-chloro-1-(3-(trifluoromethyl)benzyl)-1H-indazol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:N-(5-chloro-1-(3-(trifluoromethyl)benzyl)-1H-indazol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1383472-41-0
Molecular Formula:C₃₀H₂₉ClF₃N₇O₂
Molecular Weight:612.054
Hs Code.:

Synonyms:N-(5-chloro-1-(3-(trifluoromethyl)benzyl)-1H-indazol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of N-(5-chloro-1-(3-(trifluoromethyl)benzyl)-1H-indazol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of N-(5-chloro-1-(3-(trifluoromethyl)benzyl)-1H-indazol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxamide

There total 7 articles about N-(5-chloro-1-(3-(trifluoromethyl)benzyl)-1H-indazol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313408-94-4
7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester

: 1383475-13-5
5-chloro-1-(3-(trifluoromethyl)benzyl)-1H-indazol-4-amine

: 1383472-41-0
N-(5-chloro-1-(3-(trifluoromethyl)benzyl)-1H-indazol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: 7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester; 5-chloro-1-(3-(trifluoromethyl)benzyl)-1H-indazol-4-amine; With lithium hexamethyldisilazane; In tetrahydrofuran; at -10 - 0 ℃;

With water; sodium hydrogencarbonate; In tetrahydrofuran;

Reference yield:

: 5464-12-0
2-(4-methylpiperazinyl)ethanol

: 1383472-41-0
N-(5-chloro-1-(3-(trifluoromethyl)benzyl)-1H-indazol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / diethylene glycol dimethyl ether; mineral oil / 1 h / 40 °C / Inert atmosphere

1.2: 80 - 157 °C

2.1: ethanol / 18 h / 65 °C / Inert atmosphere

2.2: 18 h

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -10 - 0 °C

With sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; diethylene glycol dimethyl ether; mineral oil;

Reference yield:

: 2942-40-7
nitro-4 indazole

: 1383472-41-0
N-(5-chloro-1-(3-(trifluoromethyl)benzyl)-1H-indazol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 5 - 25 °C / Inert atmosphere

2.1: N,N,N′,N′-tetramethyl-N″-tert-butylguanidine / acetonitrile / 0 - 20 °C

3.1: zinc; ammonium chloride / water; methanol / 2 h / 20 °C / Saturated solution

4.1: N-chloro-succinimide; sulfuric acid / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / -10 - 0 °C

With N-chloro-succinimide; sulfuric acid; N,N,N′,N′-tetramethyl-N″-tert-butylguanidine; iodine; ammonium chloride; potassium hydroxide; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;