2(S)-<(2-benzoylphenyl)amino>-3-<4-<2-(5-methyl-1-phenyl-1H-pyrazol-3-yl)ethoxy>phenyl>propionic acid methyl ester

Base Information

• Chemical Name: 2(S)-<(2-benzoylphenyl)amino>-3-<4-<2-(5-methyl-1-phenyl-1H-pyrazol-3-yl)ethoxy>phenyl>propionic acid methyl ester
• CAS No.: 196810-34-1
• Molecular Formula: C₃₅H₃₃N₃O₄
• Molecular Weight: 559.665

Synonyms:2(S)-<(2-benzoylphenyl)amino>-3-<4-<2-(5-methyl-1-phenyl-1H-pyrazol-3-yl)ethoxy>phenyl>propionic acid methyl ester

Chemical Property of 2(S)-<(2-benzoylphenyl)amino>-3-<4-<2-(5-methyl-1-phenyl-1H-pyrazol-3-yl)ethoxy>phenyl>propionic acid methyl ester

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Technology Process of 2(S)-<(2-benzoylphenyl)amino>-3-<4-<2-(5-methyl-1-phenyl-1H-pyrazol-3-yl)ethoxy>phenyl>propionic acid methyl ester

There total 4 articles about 2(S)-<(2-benzoylphenyl)amino>-3-<4-<2-(5-methyl-1-phenyl-1H-pyrazol-3-yl)ethoxy>phenyl>propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(5-methyl-1-phenyl-1H-pyrazol-3-yl)ethanol (91027-10-0) + (S)-2-<(2-benzoylphenyl)amino>-3-(4-hydroxyphenyl)propionic acid methyl ester (196810-09-0) → 2(S)-<(2-benzoylphenyl)amino>-3-<4-<2-(5-methyl-1-phenyl-1H-pyrazol-3-yl)ethoxy>phenyl>propionic acid methyl ester (196810-34-1)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 25 ℃; for 15h;

DOI:10.1021/jm980413z

Reference yield:

3,5-dioxohexanoic acid methyl ester (29736-80-9) → 2(S)-<(2-benzoylphenyl)amino>-3-<4-<2-(5-methyl-1-phenyl-1H-pyrazol-3-yl)ethoxy>phenyl>propionic acid methyl ester (196810-34-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 180 mg / p-toluenesulfonic acid / methanol / 1.) RT, 15 min, 2.) reflux, 2 h

2: LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

3: Ph₃P, DEAD / tetrahydrofuran / 15 h / 25 °C

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;

DOI:10.1021/jm980413z

Reference yield:

methyl (5-methyl-1-phenylpyrazol-3-yl)acetate (289054-51-9) → 2(S)-<(2-benzoylphenyl)amino>-3-<4-<2-(5-methyl-1-phenyl-1H-pyrazol-3-yl)ethoxy>phenyl>propionic acid methyl ester (196810-34-1)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

2: Ph₃P, DEAD / tetrahydrofuran / 15 h / 25 °C

With lithium aluminium tetrahydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1021/jm980413z

upstream raw materials:

2-(5-methyl-1-phenyl-1H-pyrazol-3-yl)ethanol

(S)-2-<(2-benzoylphenyl)amino>-3-(4-hydroxyphenyl)propionic acid methyl ester

3,5-dioxohexanoic acid methyl ester

methyl (5-methyl-1-phenylpyrazol-3-yl)acetate

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