diethyl (acetylamino)<<3-<(diethoxyphosphinyl)methyl>phenyl>methyl>propanedioate

Base Information

Chemical Name:diethyl (acetylamino)<<3-<(diethoxyphosphinyl)methyl>phenyl>methyl>propanedioate
CAS No.:120667-51-8
Molecular Formula:C₂₁H₃₂NO₈P
Molecular Weight:457.461
Hs Code.:

Synonyms:diethyl (acetylamino)<<3-<(diethoxyphosphinyl)methyl>phenyl>methyl>propanedioate

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Chemical Property of diethyl (acetylamino)<<3-<(diethoxyphosphinyl)methyl>phenyl>methyl>propanedioate

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Technology Process of diethyl (acetylamino)<<3-<(diethoxyphosphinyl)methyl>phenyl>methyl>propanedioate

There total 9 articles about diethyl (acetylamino)<<3-<(diethoxyphosphinyl)methyl>phenyl>methyl>propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 120667-60-9
diethyl 2-(acetylamino)-2-<<3-(chloromethyl)phenyl>methyl>propanedioic acid

: 122-52-1
triethyl phosphite

: 120667-51-8
diethyl (acetylamino)<<3-<(diethoxyphosphinyl)methyl>phenyl>methyl>propanedioate

Guidance literature:: Heating;
DOI:10.1021/jm00092a005

Reference yield: 61.0%

: 120667-60-9
diethyl 2-(acetylamino)-2-<<3-(chloromethyl)phenyl>methyl>propanedioic acid

: 762-04-9
phosphonic acid diethyl ester

: 120667-51-8
diethyl (acetylamino)<<3-<(diethoxyphosphinyl)methyl>phenyl>methyl>propanedioate

Guidance literature:: With sodium hydride; In tetrahydrofuran;
DOI:10.1021/jm00127a030

Reference yield:

: 52117-00-7
2-Acetylamino-2-[(3-cyanophenyl)-methyl]-malonic acid diethyl ester

: 120667-51-8
diethyl (acetylamino)<<3-<(diethoxyphosphinyl)methyl>phenyl>methyl>propanedioate

Guidance literature:: Multi-step reaction with 4 steps

1: 68 percent / H₂, conc. aq. HCl / 10percent Pd/C / ethanol; CHCl₃ / 24 h / Ambient temperature

2: 97 percent / aq. NaOH, NaNO₂ / 5 h / Heating

3: 97 percent / thionyl chloride / CH₂Cl₂ / 20 h / Heating

4: 78 percent / Heating

With hydrogenchloride; sodium hydroxide; thionyl chloride; hydrogen; sodium nitrite; palladium on activated charcoal; In ethanol; dichloromethane; chloroform;
DOI:10.1021/jm00092a005