4-(4'-aminophenyl)-4-ethyl-1,2,5-oxadiazole

Base Information

Chemical Name:4-(4'-aminophenyl)-4-ethyl-1,2,5-oxadiazole
CAS No.:1596358-12-1
Molecular Formula:C₁₀H₁₁N₃O
Molecular Weight:189.217
Hs Code.:

Synonyms:4-(4'-aminophenyl)-4-ethyl-1,2,5-oxadiazole

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Chemical Property of 4-(4'-aminophenyl)-4-ethyl-1,2,5-oxadiazole

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Technology Process of 4-(4'-aminophenyl)-4-ethyl-1,2,5-oxadiazole

There total 3 articles about 4-(4'-aminophenyl)-4-ethyl-1,2,5-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1596358-20-1
3-ethyl-4-(4'-nitrophenyl)-2-oxide-1,2,5-oxadiazole

: 1596358-12-1
4-(4'-aminophenyl)-4-ethyl-1,2,5-oxadiazole

Guidance literature:: With ammonium chloride; zinc; In tetrahydrofuran; water; for 5h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmc.2014.02.013

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 1596358-12-1
4-(4'-aminophenyl)-4-ethyl-1,2,5-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -20 °C / Inert atmosphere

1.2: 2 h / -20 - 20 °C / Inert atmosphere

2.1: acetic acid; sodium nitrite / water / 18 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 0 - 100 °C / Inert atmosphere

3.1: zinc; ammonium chloride / water; tetrahydrofuran / 5 h / Reflux; Inert atmosphere

With n-butyllithium; ammonium chloride; acetic acid; zinc; sodium nitrite; In tetrahydrofuran; hexane; water; 1.1: |Wittig Rearrangement;
DOI:10.1016/j.bmc.2014.02.013

Reference yield:

: 49800-74-0
(E)-1-(but-1-en-1-yl)-4-nitrobenzene

: 1596358-12-1
4-(4'-aminophenyl)-4-ethyl-1,2,5-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; sodium nitrite / water / 18 h / 20 °C / Inert atmosphere

1.2: 0.5 h / 0 - 100 °C / Inert atmosphere

2.1: zinc; ammonium chloride / water; tetrahydrofuran / 5 h / Reflux; Inert atmosphere

With ammonium chloride; acetic acid; zinc; sodium nitrite; In tetrahydrofuran; water;
DOI:10.1016/j.bmc.2014.02.013