N-(2,4-difluorobenzyl)-1,8-dihydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

Base Information

Chemical Name:N-(2,4-difluorobenzyl)-1,8-dihydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS No.:1561139-48-7
Molecular Formula:C₁₇H₁₂F₂N₂O₄
Molecular Weight:346.29
Hs Code.:

Synonyms:N-(2,4-difluorobenzyl)-1,8-dihydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

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Chemical Property of N-(2,4-difluorobenzyl)-1,8-dihydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

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Technology Process of N-(2,4-difluorobenzyl)-1,8-dihydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

There total 4 articles about N-(2,4-difluorobenzyl)-1,8-dihydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1561139-41-0
N-(2,4-difluorobenzyl)-1-hydroxy-8-methoxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

: 1561139-48-7
N-(2,4-difluorobenzyl)-1,8-dihydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

Guidance literature:: N-(2,4-difluorobenzyl)-1-hydroxy-8-methoxy-2-oxo-1,2-dihydroquinoline-3-carboxamide; With boron tribromide; In dichloromethane; at 20 ℃;

With methanol; In dichloromethane; at 20 ℃;
DOI:10.1021/jm401902n

Reference yield:

: 53055-05-3
3-methoxy 2-nitrobenzaldehyde

: 1561139-48-7
N-(2,4-difluorobenzyl)-1,8-dihydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; piperidine / 15 h / 80 °C / Microwave irradiation

2.1: acetic acid; platinum(IV) oxide; hydrogen / dimethyl sulfoxide / 22 h / 20 °C

3.1: 14 h / 60 °C

4.1: boron tribromide / dichloromethane / 20 °C

4.2: 20 °C

With piperidine; platinum(IV) oxide; hydrogen; boron tribromide; acetic acid; In dichloromethane; dimethyl sulfoxide; 1.1: |Knoevenagel Condensation;
DOI:10.1021/jm401902n

Reference yield:

: 574740-53-7
diethyl 2-(3-methoxy-2-nitrobenzylidene)malonate

: 1561139-48-7
N-(2,4-difluorobenzyl)-1,8-dihydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; platinum(IV) oxide; hydrogen / dimethyl sulfoxide / 22 h / 20 °C

2.1: 14 h / 60 °C

3.1: boron tribromide / dichloromethane / 20 °C

3.2: 20 °C

With platinum(IV) oxide; hydrogen; boron tribromide; acetic acid; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm401902n