N-[(7-methyl-6,6a,7,8-tetrahydro-4H-indolo[4,3-fg]quinolin-9-ylidene)-(toluene-4-sulfonyl)-methyl]-formamide

Base Information

Chemical Name:N-[(7-methyl-6,6a,7,8-tetrahydro-4H-indolo[4,3-fg]quinolin-9-ylidene)-(toluene-4-sulfonyl)-methyl]-formamide
CAS No.:764710-82-9
Molecular Formula:C₂₄H₂₃N₃O₃S
Molecular Weight:433.531
Hs Code.:

<i>N</i>-[(7-methyl-6,6a,7,8-tetrahydro-4<i>H</i>-indolo[4,3-<i>fg</i>]quinolin-9-ylidene)-(toluene-4-sulfonyl)-methyl]-formamide

Synonyms:N-[(7-methyl-6,6a,7,8-tetrahydro-4H-indolo[4,3-fg]quinolin-9-ylidene)-(toluene-4-sulfonyl)-methyl]-formamide

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Chemical Property of N-[(7-methyl-6,6a,7,8-tetrahydro-4H-indolo[4,3-fg]quinolin-9-ylidene)-(toluene-4-sulfonyl)-methyl]-formamide

Chemical Property:

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Technology Process of N-[(7-methyl-6,6a,7,8-tetrahydro-4H-indolo[4,3-fg]quinolin-9-ylidene)-(toluene-4-sulfonyl)-methyl]-formamide

There total 6 articles about N-[(7-methyl-6,6a,7,8-tetrahydro-4H-indolo[4,3-fg]quinolin-9-ylidene)-(toluene-4-sulfonyl)-methyl]-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 764710-89-6
4-bromo-3,4-dihydro-1H-benzo[c,d]indol-5-one

: 764710-82-9
N-[(7-methyl-6,6a,7,8-tetrahydro-4H-indolo[4,3-fg]quinolin-9-ylidene)-(toluene-4-sulfonyl)-methyl]-formamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 55.7 percent / tetrahydrofuran / 24 h / 20 °C

2.1: aq. HCl / 1 h / 37 °C

3.1: 0.758 g / LiBr; TEA / CHCl₃ / 12 h / 0 - 5 °C

4.1: (-)-dibenzoyl-L-tartaric acid / acetonitrile; H₂O / 60 °C

4.2: 226 mg / NaOH / CHCl₃; H₂O / pH 9

5.1: 77 percent / tBuOK / tetrahydrofuran; 2-methyl-propan-2-ol / 0.33 h / 0 °C

With hydrogenchloride; TEA; potassium tert-butylate; (-)-Dibenzoyl-L-tartaric acid; lithium bromide; In tetrahydrofuran; chloroform; water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo049209b

Reference yield:

: 764710-84-1
4-[methyl-(2-oxo-propyl)-amino]-3,4-dihydro-1H-benzo[cd]indol-5-one

: 764710-82-9
N-[(7-methyl-6,6a,7,8-tetrahydro-4H-indolo[4,3-fg]quinolin-9-ylidene)-(toluene-4-sulfonyl)-methyl]-formamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 0.758 g / LiBr; TEA / CHCl₃ / 12 h / 0 - 5 °C

2.1: (-)-dibenzoyl-L-tartaric acid / acetonitrile; H₂O / 60 °C

2.2: 226 mg / NaOH / CHCl₃; H₂O / pH 9

3.1: 77 percent / tBuOK / tetrahydrofuran; 2-methyl-propan-2-ol / 0.33 h / 0 °C

With TEA; potassium tert-butylate; (-)-Dibenzoyl-L-tartaric acid; lithium bromide; In tetrahydrofuran; chloroform; water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo049209b

Reference yield:

: 764710-85-2
4-[N-methyl-N-acetonyl-(2',2'-ethylenedioxy)]amino-3,4-dihydro-1H-benzo[c,d]indol-5-one

: 764710-82-9
N-[(7-methyl-6,6a,7,8-tetrahydro-4H-indolo[4,3-fg]quinolin-9-ylidene)-(toluene-4-sulfonyl)-methyl]-formamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. HCl / 1 h / 37 °C

2.1: 0.758 g / LiBr; TEA / CHCl₃ / 12 h / 0 - 5 °C

3.1: (-)-dibenzoyl-L-tartaric acid / acetonitrile; H₂O / 60 °C

3.2: 226 mg / NaOH / CHCl₃; H₂O / pH 9

4.1: 77 percent / tBuOK / tetrahydrofuran; 2-methyl-propan-2-ol / 0.33 h / 0 °C

With hydrogenchloride; TEA; potassium tert-butylate; (-)-Dibenzoyl-L-tartaric acid; lithium bromide; In tetrahydrofuran; chloroform; water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo049209b