5-(4-chlorobenzoyl)-4-phenyl-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine

Base Information

• Chemical Name: 5-(4-chlorobenzoyl)-4-phenyl-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine
• CAS No.: 420849-29-2
• Molecular Formula: C₂₃H₁₄ClF₃N₃OP
• Molecular Weight: 471.806
• Mol file: 420849-29-2.mol

Synonyms:5-(4-chlorobenzoyl)-4-phenyl-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine

Chemical Property of 5-(4-chlorobenzoyl)-4-phenyl-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-chlorobenzoyl)-4-phenyl-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine

There total 4 articles about 5-(4-chlorobenzoyl)-4-phenyl-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

phenyldibromophosphine (1073-47-8) + 1-(4-chlorophenylcarboxamido)-2-(1H-1-imidazolyl)-5-trifluoromethylbenzene (380389-65-1) → 5-(4-chlorobenzoyl)-4-phenyl-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine (420849-29-2)

Guidance literature:

In triethylamine; toluene; at -20 ℃; for 1h;

DOI:10.1002/hc.10000

Reference yield:

2-chloro-3-nitro-5-trifluoromethylbenzene (121-17-5) → 5-(4-chlorobenzoyl)-4-phenyl-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine (420849-29-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / K₂CO₃ / dimethylformamide / 1.5 h / 100 - 110 °C

2: 63 percent / Fe powder; HOAc / propan-2-ol / 1.5 h / Heating

3: pyridine / 3.5 h / -5 - 20 °C

4: 75 percent / triethylamine; toluene / 1 h / -20 °C

With iron; potassium carbonate; acetic acid; In pyridine; triethylamine; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

DOI:10.1002/hc.10000

Reference yield:

1-(2-nitro-4-trifluoromethylphenyl)-1H-imidazole (25373-61-9) → 5-(4-chlorobenzoyl)-4-phenyl-7-trifluoromethyl-4,5-dihydrobenzo[e]imidazo[2,1-c][1,4,2]diazaphosphinine (420849-29-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 63 percent / Fe powder; HOAc / propan-2-ol / 1.5 h / Heating

2: pyridine / 3.5 h / -5 - 20 °C

3: 75 percent / triethylamine; toluene / 1 h / -20 °C

With iron; acetic acid; In pyridine; triethylamine; isopropyl alcohol; toluene;

DOI:10.1002/hc.10000

upstream raw materials:

phenyldibromophosphine

1-(4-chlorophenylcarboxamido)-2-(1H-1-imidazolyl)-5-trifluoromethylbenzene

2-chloro-3-nitro-5-trifluoromethylbenzene

1-(2-nitro-4-trifluoromethylphenyl)-1H-imidazole