(2R,3S)-2-[4-(2-Methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-piperidine-1,3-dicarboxylic acid di-tert-butyl ester

Base Information

Chemical Name:(2R,3S)-2-[4-(2-Methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-piperidine-1,3-dicarboxylic acid di-tert-butyl ester
CAS No.:441298-10-8
Molecular Formula:C₃₃H₄₂N₂O₇S
Molecular Weight:610.772
Hs Code.:

Synonyms:(2R,3S)-2-[4-(2-Methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-piperidine-1,3-dicarboxylic acid di-tert-butyl ester

Suppliers and Price of (2R,3S)-2-[4-(2-Methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-piperidine-1,3-dicarboxylic acid di-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S)-2-[4-(2-Methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-piperidine-1,3-dicarboxylic acid di-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S)-2-[4-(2-Methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-piperidine-1,3-dicarboxylic acid di-tert-butyl ester

There total 8 articles about (2R,3S)-2-[4-(2-Methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-piperidine-1,3-dicarboxylic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 146398-01-8
(R)-4-hydroxy-2-{[(phenylmethoxy)carbonyl]amino}butanoic acid 1,1-dimethylethyl ester

: 441298-10-8
(2R,3S)-2-[4-(2-Methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-piperidine-1,3-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 97 percent / TEA / CH₂Cl₂

2: 60 percent / NaH / dimethylformamide / 20 °C

3: 95 percent / K₂CO₃ / dimethylformamide

4: 90 percent / LDA / tetrahydrofuran

5: 90 percent / Oxone / methanol; H₂O

6: 67 percent / 9-BBN / tetrahydrofuran

7: 71 percent / pyridinium dichromate / CH₂Cl₂

8: 95 percent / H₂ / Pd-C / methanol

9: 90 percent / tetrahydrofuran; H₂O

10: 65 percent / K₂CO₃ / dimethylformamide

With Oxone; dipyridinium dichromate; 9-borabicyclo[3.3.1]nonane dimer; TEA; hydrogen; sodium hydride; potassium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.06.049

Reference yield:

: 71449-08-6
(2R)-2-{[(benzyloxy)carbonyl]amino}-4-tert-butoxy-4-oxobutanoic acid

: 441298-10-8
(2R,3S)-2-[4-(2-Methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-piperidine-1,3-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 60 percent / BH₃ / tetrahydrofuran

2: 97 percent / TEA / CH₂Cl₂

3: 60 percent / NaH / dimethylformamide / 20 °C

4: 95 percent / K₂CO₃ / dimethylformamide

5: 90 percent / LDA / tetrahydrofuran

6: 90 percent / Oxone / methanol; H₂O

7: 67 percent / 9-BBN / tetrahydrofuran

8: 71 percent / pyridinium dichromate / CH₂Cl₂

9: 95 percent / H₂ / Pd-C / methanol

10: 90 percent / tetrahydrofuran; H₂O

11: 65 percent / K₂CO₃ / dimethylformamide

With Oxone; dipyridinium dichromate; 9-borabicyclo[3.3.1]nonane dimer; TEA; borane; hydrogen; sodium hydride; potassium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.06.049

Reference yield:

: 761435-43-2
3-benzyloxycarbonylamino-4-methanesulfonyloxy-butyric acid tert-butyl ester

: 441298-10-8
(2R,3S)-2-[4-(2-Methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-piperidine-1,3-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 60 percent / NaH / dimethylformamide / 20 °C

2: 95 percent / K₂CO₃ / dimethylformamide

3: 90 percent / LDA / tetrahydrofuran

4: 90 percent / Oxone / methanol; H₂O

5: 67 percent / 9-BBN / tetrahydrofuran

6: 71 percent / pyridinium dichromate / CH₂Cl₂

7: 95 percent / H₂ / Pd-C / methanol

8: 90 percent / tetrahydrofuran; H₂O

9: 65 percent / K₂CO₃ / dimethylformamide

With Oxone; dipyridinium dichromate; 9-borabicyclo[3.3.1]nonane dimer; hydrogen; sodium hydride; potassium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.06.049