(S)-2-(3-((1R,2R)-2-aminocyclohexyl)thioureido)-N,N,3,3-tetramethylbutanamide

Base Information

Chemical Name:(S)-2-(3-((1R,2R)-2-aminocyclohexyl)thioureido)-N,N,3,3-tetramethylbutanamide
CAS No.:462632-53-7
Molecular Formula:C₁₅H₃₀N₄OS
Molecular Weight:314.495
Hs Code.:

Synonyms:(S)-2-(3-((1R,2R)-2-aminocyclohexyl)thioureido)-N,N,3,3-tetramethylbutanamide

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Chemical Property of (S)-2-(3-((1R,2R)-2-aminocyclohexyl)thioureido)-N,N,3,3-tetramethylbutanamide

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Technology Process of (S)-2-(3-((1R,2R)-2-aminocyclohexyl)thioureido)-N,N,3,3-tetramethylbutanamide

There total 4 articles about (S)-2-(3-((1R,2R)-2-aminocyclohexyl)thioureido)-N,N,3,3-tetramethylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 20439-47-8
(1R,2R)-1,2-diaminocyclohexane

: 764650-93-3
(S)-2-isothiocyanato-N,N,3,3-tetramethylbutanamide

: 462632-53-7
(S)-2-(3-((1R,2R)-2-aminocyclohexyl)thioureido)-N,N,3,3-tetramethylbutanamide

Guidance literature:: In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1002/chem.201405730

Reference yield:

: (S)-2-amino-3,3,N,N-tetramethylbutyramide hydrochloride

: 463-71-8
thiophosgene

: 20439-47-8
(1R,2R)-1,2-diaminocyclohexane

: 462632-53-7
(S)-2-(3-((1R,2R)-2-aminocyclohexyl)thioureido)-N,N,3,3-tetramethylbutanamide

Guidance literature:: (S)-2-amino-3,3,N,N-tetramethylbutyramide hydrochloride; thiophosgene; With sodium hydrogencarbonate; In dichloromethane; water; at 0 ℃; for 0.5h;

(1R,2R)-1,2-diaminocyclohexane; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.5h; Further stages.;
DOI:10.1021/ja027246j

Reference yield:

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 462632-53-7
(S)-2-(3-((1R,2R)-2-aminocyclohexyl)thioureido)-N,N,3,3-tetramethylbutanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: HBTU; DIPEA / CH₂Cl₂ / 1.5 h

1.2: HCl / dioxane / 2 h / 20 °C

2.1: NaHCO₃ / CH₂Cl₂; H₂O / 0.5 h / 0 °C

2.2: 2.13 g / DIPEA / CH₂Cl₂ / 0.5 h

With sodium hydrogencarbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water;
DOI:10.1021/ja027246j