N-(4-(7-chloro-2,3-dihydro-5-hydroxy-2,2,4,4,5-pentadeutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

Base Information

Chemical Name:N-(4-(7-chloro-2,3-dihydro-5-hydroxy-2,2,4,4,5-pentadeutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide
CAS No.:1296212-20-8
Molecular Formula:C₂₆H₂₅ClN₂O₃
Molecular Weight:453.909
Hs Code.:

Synonyms:N-(4-(7-chloro-2,3-dihydro-5-hydroxy-2,2,4,4,5-pentadeutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

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Chemical Property of N-(4-(7-chloro-2,3-dihydro-5-hydroxy-2,2,4,4,5-pentadeutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

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Technology Process of N-(4-(7-chloro-2,3-dihydro-5-hydroxy-2,2,4,4,5-pentadeutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

There total 7 articles about N-(4-(7-chloro-2,3-dihydro-5-hydroxy-2,2,4,4,5-pentadeutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1296212-28-6
N-(4-(7-chloro-2,3-dihydro-5-oxo-2,2,4,4-tetradeutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

: 1296212-20-8
N-(4-(7-chloro-2,3-dihydro-5-hydroxy-2,2,4,4,5-pentadeutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

Guidance literature:: With sodium borodeuteride; d⁽⁴⁾-methanol; at 0 ℃; for 2h;

Reference yield:

: 317374-08-6
2-methyl-4-(2-methylbenzoylamino)benzoic acid

: 1296212-20-8
N-(4-(7-chloro-2,3-dihydro-5-hydroxy-2,2,4,4,5-pentadeutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux

2.1: triethylamine / dichloromethane / 4 h / 0 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

3.2: 0 °C

4.1: manganese(IV) oxide / dichloromethane / 8 h / Reflux

5.1: d⁽⁴⁾-methanol; sodium hydroxide / 18 h / 20 °C / Inert atmosphere

6.1: d⁽⁴⁾-methanol; sodium borodeuteride / 2 h / 0 °C

With manganese(IV) oxide; thionyl chloride; sodium borodeuteride; d⁽⁴⁾-methanol; tetrabutyl ammonium fluoride; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1296212-21-9
ethyl 4-(5-chloro-2-nitrophenyl)-4-(trimethylsilyloxy)butanoate

: 1296212-20-8
N-(4-(7-chloro-2,3-dihydro-5-hydroxy-2,2,4,4,5-pentadeutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: citric acid / ethanol; water / 1.5 h / 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 1 h / 30 °C

3.2: 3 h / 760.05 Torr / Inert atmosphere

3.3: 72 h / 20 °C

4.1: boron trifluoride diethyl etherate; sodium borodeuteride / tetrahydrofuran / 3 h / 0 - 20 °C

5.1: triethylamine / dichloromethane / 4 h / 0 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

6.2: 0 °C

7.1: manganese(IV) oxide / dichloromethane / 8 h / Reflux

8.1: d⁽⁴⁾-methanol; sodium hydroxide / 18 h / 20 °C / Inert atmosphere

9.1: d⁽⁴⁾-methanol; sodium borodeuteride / 2 h / 0 °C

With 1H-imidazole; manganese(IV) oxide; sodium borodeuteride; d⁽⁴⁾-methanol; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; water; triethylamine; citric acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;