6-Phenylethynyl-3-(toluene-4-sulfonyl)-7-oxa-3-aza-bicyclo[4.1.0]heptane

Base Information

Chemical Name:6-Phenylethynyl-3-(toluene-4-sulfonyl)-7-oxa-3-aza-bicyclo[4.1.0]heptane
CAS No.:87955-60-0
Molecular Formula:C₂₀H₁₉NO₃S
Molecular Weight:353.442
Hs Code.:

Synonyms:6-Phenylethynyl-3-(toluene-4-sulfonyl)-7-oxa-3-aza-bicyclo[4.1.0]heptane

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Chemical Property of 6-Phenylethynyl-3-(toluene-4-sulfonyl)-7-oxa-3-aza-bicyclo[4.1.0]heptane

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Technology Process of 6-Phenylethynyl-3-(toluene-4-sulfonyl)-7-oxa-3-aza-bicyclo[4.1.0]heptane

There total 3 articles about 6-Phenylethynyl-3-(toluene-4-sulfonyl)-7-oxa-3-aza-bicyclo[4.1.0]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 87955-42-8
4-Phenylethynyl-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridine

: 87955-60-0
6-Phenylethynyl-3-(toluene-4-sulfonyl)-7-oxa-3-aza-bicyclo[4.1.0]heptane

Guidance literature:: With disodium hydrogenphosphate; sodium dihydrogenphosphate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; for 4h; Ambient temperature;

Reference yield:

: 536-74-3
phenylacetylene

: 87955-60-0
6-Phenylethynyl-3-(toluene-4-sulfonyl)-7-oxa-3-aza-bicyclo[4.1.0]heptane

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) C₂H₅MgBr / 1.) THF, reflux, 3 h; 2.) reflux, 90 min

2: 79 percent / POCl₃, pyridine / 2 h / 80 °C

3: 59 percent / 3-chloroperoxybenzoic acid, Na₂HPO₄, NaH₂PO₄ / CH₂Cl₂; H₂O / 4 h / Ambient temperature

With pyridine; disodium hydrogenphosphate; sodium dihydrogenphosphate; ethylmagnesium bromide; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In dichloromethane; water;

Reference yield:

: 87943-01-9
4-(phenylethynyl)-1-tosylpiperidin-4-ol

: 87955-60-0
6-Phenylethynyl-3-(toluene-4-sulfonyl)-7-oxa-3-aza-bicyclo[4.1.0]heptane

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / POCl₃, pyridine / 2 h / 80 °C

2: 59 percent / 3-chloroperoxybenzoic acid, Na₂HPO₄, NaH₂PO₄ / CH₂Cl₂; H₂O / 4 h / Ambient temperature

With pyridine; disodium hydrogenphosphate; sodium dihydrogenphosphate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In dichloromethane; water;