(E)-3-[[(R)-1-(2-Phenylselanyl-ethyl)-pentyl]-(2-trimethylsilanyl-ethanesulfonyl)-amino]-acrylic acid benzyl ester

Base Information

Chemical Name:(E)-3-[[(R)-1-(2-Phenylselanyl-ethyl)-pentyl]-(2-trimethylsilanyl-ethanesulfonyl)-amino]-acrylic acid benzyl ester
CAS No.:292615-19-1
Molecular Formula:C₂₈H₄₁NO₄SSeSi
Molecular Weight:594.749
Hs Code.:

Synonyms:(E)-3-[[(R)-1-(2-Phenylselanyl-ethyl)-pentyl]-(2-trimethylsilanyl-ethanesulfonyl)-amino]-acrylic acid benzyl ester

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Chemical Property of (E)-3-[[(R)-1-(2-Phenylselanyl-ethyl)-pentyl]-(2-trimethylsilanyl-ethanesulfonyl)-amino]-acrylic acid benzyl ester

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Technology Process of (E)-3-[[(R)-1-(2-Phenylselanyl-ethyl)-pentyl]-(2-trimethylsilanyl-ethanesulfonyl)-amino]-acrylic acid benzyl ester

There total 5 articles about (E)-3-[[(R)-1-(2-Phenylselanyl-ethyl)-pentyl]-(2-trimethylsilanyl-ethanesulfonyl)-amino]-acrylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14447-01-9
benzyl prop-2-ynoate

: 2-Trimethylsilanyl-ethanesulfonic acid [(R)-1-(2-phenylselanyl-ethyl)-pentyl]-amide

: 292615-19-1
(E)-3-[[(R)-1-(2-Phenylselanyl-ethyl)-pentyl]-(2-trimethylsilanyl-ethanesulfonyl)-amino]-acrylic acid benzyl ester

Guidance literature:: With 4-methyl-morpholine; In acetonitrile; at 0 ℃; for 2h;
DOI:10.1021/ol006094z

Reference yield:

: 1666-13-3
diphenyl diselenide

: 292615-19-1
(E)-3-[[(R)-1-(2-Phenylselanyl-ethyl)-pentyl]-(2-trimethylsilanyl-ethanesulfonyl)-amino]-acrylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₄ / ethanol / 2 h / 20 °C

2: N-methylmorpholine / acetonitrile / 2 h / 0 °C

With 4-methyl-morpholine; sodium tetrahydroborate; In ethanol; acetonitrile; 1: Substitution / 2: Addition;
DOI:10.1021/ol006094z

Reference yield:

: 135307-19-6
(S)-(+)-1,3-heptanetriol

: 292615-19-1
(E)-3-[[(R)-1-(2-Phenylselanyl-ethyl)-pentyl]-(2-trimethylsilanyl-ethanesulfonyl)-amino]-acrylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: TEA; DMAP / CH₂Cl₂ / 5 h / 20 °C

2.1: Ph₃P; DEAD / tetrahydrofuran / 12 h / 20 °C

2.2: conc. HCl / ethanol / 12 h / Heating

2.3: TEA / CH₂Cl₂ / 3 h / 0 °C

3.1: NaBH₄ / ethanol / 2 h / 20 °C

4.1: N-methylmorpholine / acetonitrile / 2 h / 0 °C

With 4-methyl-morpholine; dmap; sodium tetrahydroborate; TEA; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; 1.1: silylation / 2.1: Mitsunobu reaction / 2.2: desilylation / 2.3: Tosylation / 3.1: Substitution / 4.1: Addition;
DOI:10.1021/ol006094z