C₂₂H₂₁N₃O₄

Base Information

• Chemical Name: C₂₂H₂₁N₃O₄
• CAS No.: 1332848-35-7
• Molecular Formula: C₂₂H₂₁N₃O₄
• Molecular Weight: 391.426
• Mol file: 1332848-35-7.mol

Synonyms:C₂₂H₂₁N₃O₄

Chemical Property of C₂₂H₂₁N₃O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₁N₃O₄

There total 1 articles about C₂₂H₂₁N₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Nα-Boc-N1-Cbz-L-tryptophan methyl ester (1116188-99-8) + L-N-Boc-Ala (15761-38-3) → C22H21N3O4 (1332848-35-7)

Guidance literature:

Nα-Boc-N1-Cbz-L-tryptophan methyl ester; With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 1h; Inert atmosphere;

L-N-Boc-Ala; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 23 ℃; for 13.5h; Further stages; Inert atmosphere;

DOI:10.1021/ja206743v

Reference yield: 69.2%

C22H21N3O4 (1332848-35-7) → C22H20BrN3O4 (1332848-37-9)

Guidance literature:

With pyridinium hydrobromide perbromide; In 2,2,2-trifluoroethanol; at 23 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1021/ja206743v

Reference yield:

C22H21N3O4 (1332848-35-7) → C25H25N3O4 (1332848-47-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridinium hydrobromide perbromide / 2,2,2-trifluoroethanol / 0.33 h / 23 °C / Inert atmosphere

2: silver hexafluoroantimonate; 18-crown-6 ether / dichloromethane / 1 h / 23 °C / Inert atmosphere

With silver hexafluoroantimonate; pyridinium hydrobromide perbromide; 18-crown-6 ether; In dichloromethane; 2,2,2-trifluoroethanol;

DOI:10.1021/ja206743v

upstream raw materials:

Nα-Boc-N1-Cbz-L-tryptophan methyl ester

L-N-Boc-Ala

Downstream raw materials:

C₄₆H₄₂N₆O₈

C₂₆H₂₃N₃O₄S

C₂₆H₂₃N₃O₄S

C₂₅H₂₅N₃O₄