3-(4-bromobenzyl)-7-(5-chloropyridin-3-yl)-3-methyl-3,4-dihydronaphthalen-1(2H)-one

Base Information

Chemical Name:3-(4-bromobenzyl)-7-(5-chloropyridin-3-yl)-3-methyl-3,4-dihydronaphthalen-1(2H)-one
CAS No.:1338094-75-9
Molecular Formula:C₂₃H₁₉BrClNO
Molecular Weight:440.767
Hs Code.:

Synonyms:3-(4-bromobenzyl)-7-(5-chloropyridin-3-yl)-3-methyl-3,4-dihydronaphthalen-1(2H)-one

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Chemical Property of 3-(4-bromobenzyl)-7-(5-chloropyridin-3-yl)-3-methyl-3,4-dihydronaphthalen-1(2H)-one

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Technology Process of 3-(4-bromobenzyl)-7-(5-chloropyridin-3-yl)-3-methyl-3,4-dihydronaphthalen-1(2H)-one

There total 6 articles about 3-(4-bromobenzyl)-7-(5-chloropyridin-3-yl)-3-methyl-3,4-dihydronaphthalen-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 872041-85-5
(5-chloro-3-pyridyl)boronic acid

: 1338094-74-8
7-bromo-3-(4-bromobenzyl)-3-methyl-3,4-dihydronaphthalen-1(2H)-one

: 1338094-75-9
3-(4-bromobenzyl)-7-(5-chloropyridin-3-yl)-3-methyl-3,4-dihydronaphthalen-1(2H)-one

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; for 4.05h;

Reference yield:

: 6186-22-7
4-bromophenyl acetone

: 1338094-75-9
3-(4-bromobenzyl)-7-(5-chloropyridin-3-yl)-3-methyl-3,4-dihydronaphthalen-1(2H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine; titanium tetrachloride / toluene / 24 h / 20 °C / Cooling with ice

2.1: magnesium / diethyl ether / 0.5 h / Reflux

2.2: 0.67 h / 0 - 20 °C

3.1: potassium hydroxide; water / ethanol / 15 h / 60 °C

4.1: 185 - 195 °C

5.1: polyphosphoric acid / 2 h / 120 °C

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4.05 h / 90 °C

With pyridine; water; titanium tetrachloride; sodium carbonate; magnesium; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; diethyl ether; ethanol; water; toluene;

Reference yield:

: 1338094-70-4
diethyl 2-(1-(4-bromophenyl)propan-2-ylidene)malonate

: 1338094-75-9
3-(4-bromobenzyl)-7-(5-chloropyridin-3-yl)-3-methyl-3,4-dihydronaphthalen-1(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: magnesium / diethyl ether / 0.5 h / Reflux

1.2: 0.67 h / 0 - 20 °C

2.1: potassium hydroxide; water / ethanol / 15 h / 60 °C

3.1: 185 - 195 °C

4.1: polyphosphoric acid / 2 h / 120 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4.05 h / 90 °C

With water; sodium carbonate; magnesium; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; diethyl ether; ethanol; water;