4'-demethyl-4'-O-(benzyloxycarbonyl)-4β-(2-formylethyl)-4-desoxypodophyllotoxin

Base Information

Chemical Name:4'-demethyl-4'-O-(benzyloxycarbonyl)-4β-(2-formylethyl)-4-desoxypodophyllotoxin
CAS No.:147238-67-3
Molecular Formula:C₃₂H₃₀O₁₀
Molecular Weight:574.584
Hs Code.:

Synonyms:4'-demethyl-4'-O-(benzyloxycarbonyl)-4β-(2-formylethyl)-4-desoxypodophyllotoxin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4'-demethyl-4'-O-(benzyloxycarbonyl)-4β-(2-formylethyl)-4-desoxypodophyllotoxin

Chemical Property:

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Technology Process of 4'-demethyl-4'-O-(benzyloxycarbonyl)-4β-(2-formylethyl)-4-desoxypodophyllotoxin

There total 2 articles about 4'-demethyl-4'-O-(benzyloxycarbonyl)-4β-(2-formylethyl)-4-desoxypodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23363-33-9
4'-demethyl-4'-O-(benzoyloxycarbonyl)epipodophyllotoxin

: 147238-67-3
4'-demethyl-4'-O-(benzyloxycarbonyl)-4β-(2-formylethyl)-4-desoxypodophyllotoxin

Guidance literature:: Multi-step reaction with 2 steps

1: 95.8 percent / BF₃*Et₂O / CH₂Cl₂ / 1 h / 0 °C

2: 1.) 2M BH₃*Me₂S, 2.) pyridinium chlorochromate / 1.) THF, from 0 deg C to RT, 1 h, 2.) CH₂Cl₂, RT, 10 h

With dimethylsulfide borane complex; boron trifluoride diethyl etherate; pyridinium chlorochromate; In dichloromethane;
DOI:10.1021/jm00064a002

Reference yield:

: 147238-65-1
4'-demethyl-4'-O-(benzyloxycarbonyl)-4β-allyl-4-desoxypodophyllotoxin

: 147238-67-3
4'-demethyl-4'-O-(benzyloxycarbonyl)-4β-(2-formylethyl)-4-desoxypodophyllotoxin

Guidance literature:: With dimethylsulfide borane complex; pyridinium chlorochromate; Yield given. Multistep reaction; 1.) THF, from 0 deg C to RT, 1 h, 2.) CH₂Cl₂, RT, 10 h;
DOI:10.1021/jm00064a002