4-[4-{2-octyloxyethylaminomethyl}benzyloxy]-3,5-bis(hydroxymethyl)phenylacetylene

Base Information

Chemical Name:4-[4-{2-octyloxyethylaminomethyl}benzyloxy]-3,5-bis(hydroxymethyl)phenylacetylene
CAS No.:1251827-68-5
Molecular Formula:C₂₈H₃₉NO₄
Molecular Weight:453.622
Hs Code.:

Synonyms:4-[4-{2-octyloxyethylaminomethyl}benzyloxy]-3,5-bis(hydroxymethyl)phenylacetylene

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Chemical Property of 4-[4-{2-octyloxyethylaminomethyl}benzyloxy]-3,5-bis(hydroxymethyl)phenylacetylene

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Technology Process of 4-[4-{2-octyloxyethylaminomethyl}benzyloxy]-3,5-bis(hydroxymethyl)phenylacetylene

There total 5 articles about 4-[4-{2-octyloxyethylaminomethyl}benzyloxy]-3,5-bis(hydroxymethyl)phenylacetylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1100090-79-6
4-{4-trimethylsilylethynyl-2,6-(bishydroxymethyl)-1-phenoxymethyl}benzaldehyde

: 59970-19-3
2-aminoethyl n-octyl ether

: 1251827-68-5
4-[4-{2-octyloxyethylaminomethyl}benzyloxy]-3,5-bis(hydroxymethyl)phenylacetylene

Guidance literature:: 4-{4-trimethylsilylethynyl-2,6-(bishydroxymethyl)-1-phenoxymethyl}benzaldehyde; 2-aminoethyl n-octyl ether; In methanol; at 20 ℃; for 24h; Inert atmosphere; Molecular sieve;

With sodium tetrahydroborate; In methanol; for 36h; Inert atmosphere;
DOI:10.1021/ma101424x

Reference yield:

: 1100090-77-4
C₁₆H₁₅BrO₄

: 1251827-68-5
4-[4-{2-octyloxyethylaminomethyl}benzyloxy]-3,5-bis(hydroxymethyl)phenylacetylene

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine; triphenylphosphine

2.1: methanol / 24 h / 20 °C / Inert atmosphere; Molecular sieve

2.2: 36 h / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine; In methanol;
DOI:10.1021/ma101424x

Reference yield:

: 111-83-1
1-bromo-octane

: 1251827-68-5
4-[4-{2-octyloxyethylaminomethyl}benzyloxy]-3,5-bis(hydroxymethyl)phenylacetylene

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; paraffin oil / 0 °C / Inert atmosphere; Reflux

1.2: 7 h / 20 °C / Inert atmosphere; Reflux

2.1: methanol / 24 h / 20 °C / Inert atmosphere; Molecular sieve

2.2: 36 h / Inert atmosphere

With sodium hydride; In tetrahydrofuran; methanol; paraffin oil;
DOI:10.1021/ma101424x