3-(4-methoxyphenyl)-4-phenyl-5-(o-tolyl)-2-(p-tolyl)thiophene

Base Information

• Chemical Name: 3-(4-methoxyphenyl)-4-phenyl-5-(o-tolyl)-2-(p-tolyl)thiophene
• CAS No.: 1332705-39-1
• Molecular Formula: C₃₁H₂₆OS
• Molecular Weight: 446.613
• Mol file: 1332705-39-1.mol

Synonyms:3-(4-methoxyphenyl)-4-phenyl-5-(o-tolyl)-2-(p-tolyl)thiophene

Chemical Property of 3-(4-methoxyphenyl)-4-phenyl-5-(o-tolyl)-2-(p-tolyl)thiophene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-methoxyphenyl)-4-phenyl-5-(o-tolyl)-2-(p-tolyl)thiophene

There total 6 articles about 3-(4-methoxyphenyl)-4-phenyl-5-(o-tolyl)-2-(p-tolyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

3-bromo-4-(4-methoxyphenyl)-2-(o-tolyl)-5-(p-tolyl)thiophene (1332705-36-8) + phenylboronic acid (98-80-6) → 3-(4-methoxyphenyl)-4-phenyl-5-(o-tolyl)-2-(p-tolyl)thiophene (1332705-39-1)

Guidance literature:

With potassium phosphate; 3,3'-(3,4-bis(dichloromethylene)cyclobut-1-ene-1,2-diyl)bis(1-methyl-1H-imidazolium) bis(tetrafluoroborate); palladium diacetate; In 1,4-dioxane; toluene; at 90 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jo201317t

Reference yield:

3,4-dibromo-2-o-tolyl-5-p-tolylthiophene (1332705-28-8) → 3-(4-methoxyphenyl)-4-phenyl-5-(o-tolyl)-2-(p-tolyl)thiophene (1332705-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate; 3,3'-(3,4-bis(dichloromethylene)cyclobut-1-ene-1,2-diyl)bis(1-methyl-1H-imidazolium) bis(tetrafluoroborate); palladium diacetate / 1,4-dioxane; toluene / 14 h / 80 °C / Inert atmosphere

2: potassium phosphate; 3,3'-(3,4-bis(dichloromethylene)cyclobut-1-ene-1,2-diyl)bis(1-methyl-1H-imidazolium) bis(tetrafluoroborate); palladium diacetate / 1,4-dioxane; toluene / 16 h / 90 °C / Inert atmosphere

With potassium phosphate; 3,3'-(3,4-bis(dichloromethylene)cyclobut-1-ene-1,2-diyl)bis(1-methyl-1H-imidazolium) bis(tetrafluoroborate); palladium diacetate; In 1,4-dioxane; toluene; 1: Suzuki coupling / 2: Suzuki coupling;

DOI:10.1021/jo201317t

Reference yield:

4-methylphenylboronic acid (5720-05-8) → 3-(4-methoxyphenyl)-4-phenyl-5-(o-tolyl)-2-(p-tolyl)thiophene (1332705-39-1)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium phosphate; 3,3'-(3,4-bis(dichloromethylene)cyclobut-1-ene-1,2-diyl)bis(1-methyl-1H-imidazolium) bis(tetrafluoroborate); palladium diacetate / toluene / 8 h / 70 °C / Inert atmosphere

2: potassium phosphate; 3,3'-(3,4-bis(dichloromethylene)cyclobut-1-ene-1,2-diyl)bis(1-methyl-1H-imidazolium) bis(tetrafluoroborate); palladium diacetate / toluene / 10 h / 80 °C / Inert atmosphere

3: potassium phosphate; 3,3'-(3,4-bis(dichloromethylene)cyclobut-1-ene-1,2-diyl)bis(1-methyl-1H-imidazolium) bis(tetrafluoroborate); palladium diacetate / 1,4-dioxane; toluene / 14 h / 80 °C / Inert atmosphere

4: potassium phosphate; 3,3'-(3,4-bis(dichloromethylene)cyclobut-1-ene-1,2-diyl)bis(1-methyl-1H-imidazolium) bis(tetrafluoroborate); palladium diacetate / 1,4-dioxane; toluene / 16 h / 90 °C / Inert atmosphere

With potassium phosphate; 3,3'-(3,4-bis(dichloromethylene)cyclobut-1-ene-1,2-diyl)bis(1-methyl-1H-imidazolium) bis(tetrafluoroborate); palladium diacetate; In 1,4-dioxane; toluene; 1: Suzuki coupling / 2: Suzuki coupling / 3: Suzuki coupling / 4: Suzuki coupling;

DOI:10.1021/jo201317t

upstream raw materials:

3,4-dibromo-2-o-tolyl-5-p-tolylthiophene

3-bromo-4-(4-methoxyphenyl)-2-(o-tolyl)-5-(p-tolyl)thiophene

phenylboronic acid

2,3,4-tribromo-5-p-tolylthiophene