2-(4-fluoro-phenyl)-1-(2-hydroxy-ethyl)-1H-benzoimidazole-5-carbonitrile

Base Information

Chemical Name:2-(4-fluoro-phenyl)-1-(2-hydroxy-ethyl)-1H-benzoimidazole-5-carbonitrile
CAS No.:475490-07-4
Molecular Formula:C₁₆H₁₂FN₃O
Molecular Weight:281.289
Hs Code.:

2-(4-fluoro-phenyl)-1-(2-hydroxy-ethyl)-1<i>H</i>-benzoimidazole-5-carbonitrile

Synonyms:2-(4-fluoro-phenyl)-1-(2-hydroxy-ethyl)-1H-benzoimidazole-5-carbonitrile

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Chemical Property of 2-(4-fluoro-phenyl)-1-(2-hydroxy-ethyl)-1H-benzoimidazole-5-carbonitrile

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Technology Process of 2-(4-fluoro-phenyl)-1-(2-hydroxy-ethyl)-1H-benzoimidazole-5-carbonitrile

There total 3 articles about 2-(4-fluoro-phenyl)-1-(2-hydroxy-ethyl)-1H-benzoimidazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 459-57-4
4-fluorobenzaldehyde

: 221289-93-6
3-amino-4-((2-hydroxyethyl)amino)benzonitrile

: 475490-07-4
2-(4-fluoro-phenyl)-1-(2-hydroxy-ethyl)-1H-benzoimidazole-5-carbonitrile

Guidance literature:: 4-fluorobenzaldehyde; With sodium disulfite; In ethanol; water;

3-amino-4-((2-hydroxyethyl)amino)benzonitrile; With N,N-dimethyl-formamide; at 130 ℃; for 4h;
DOI:10.1016/S0968-0896(02)00103-7

Reference yield:

: 939-80-0
4-chloro-3-nitrobenzonitrile

: 475490-07-4
2-(4-fluoro-phenyl)-1-(2-hydroxy-ethyl)-1H-benzoimidazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / DMF / Heating

2.1: 89.5 percent / hydrogen / 10 percent Pd/C / ethanol / 2068.59 Torr

3.1: sodium metabisulfite / ethanol; H₂O

3.2: 67 percent / DMF / 4 h / 130 °C

With sodium disulfite; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In ethanol; water;
DOI:10.1016/S0968-0896(02)00103-7

Reference yield:

: 90349-40-9
4-(2'-hydroxyethyl)amino-3-nitrobenzonitrile

: 475490-07-4
2-(4-fluoro-phenyl)-1-(2-hydroxy-ethyl)-1H-benzoimidazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89.5 percent / hydrogen / 10 percent Pd/C / ethanol / 2068.59 Torr

2.1: sodium metabisulfite / ethanol; H₂O

2.2: 67 percent / DMF / 4 h / 130 °C

With sodium disulfite; hydrogen; palladium on activated charcoal; In ethanol; water;
DOI:10.1016/S0968-0896(02)00103-7