1-(3-chlorophenyl)-N-1-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}propane-1,3-diamine hydrochloride

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Chemical Name:1-(3-chlorophenyl)-N-1-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}propane-1,3-diamine hydrochloride
CAS No.:1400669-94-4
Molecular Formula:C₂₄H₂₈ClN₉*ClH
Molecular Weight:514.461
Hs Code.:

Synonyms:1-(3-chlorophenyl)-N-1-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}propane-1,3-diamine hydrochloride

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Chemical Property of 1-(3-chlorophenyl)-N-1-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}propane-1,3-diamine hydrochloride

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Technology Process of 1-(3-chlorophenyl)-N-1-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}propane-1,3-diamine hydrochloride

There total 8 articles about 1-(3-chlorophenyl)-N-1-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}propane-1,3-diamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400670-46-3
(3-(3-chloro-phenyl)-3-{4-[8-(4-methyl-piperazin-1-yl)-imidazo[1,2-a]pyrazin-3-yl]-pyrimidin-2-ylamino}-propyl)-carbamic acid tert-butyl ester

: 1400669-94-4
1-(3-chlorophenyl)-N-1-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}propane-1,3-diamine hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; water; at 20 ℃; for 15h;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1400669-94-4
1-(3-chlorophenyl)-N-1-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}propane-1,3-diamine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 15 h / Reflux

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

3: 2 h / 140 °C

4: hydrogenchloride / ethanol; water / 15 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 21667-62-9
3-chlorobenzoylacetonitrile

: 1400669-94-4
1-(3-chlorophenyl)-N-1-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}propane-1,3-diamine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 60 °C / Inert atmosphere

2: tetrahydrofuran / 0.5 h

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 5 °C

4: hydrazine hydrate / tetrahydrofuran; methanol / 2 h / 55 °C

5: 2 h / 140 °C

6: hydrogenchloride / ethanol; water / 15 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; water;