ethyl 4-<<3-(3-formyl-4-nitrophenoxy)propyl>sulfonyl>-1-piperidinecarboxylate

Base Information

Chemical Name:ethyl 4-<<3-(3-formyl-4-nitrophenoxy)propyl>sulfonyl>-1-piperidinecarboxylate
CAS No.:145624-48-2
Molecular Formula:C₁₈H₂₄N₂O₈S
Molecular Weight:428.463
Hs Code.:

Synonyms:ethyl 4-<<3-(3-formyl-4-nitrophenoxy)propyl>sulfonyl>-1-piperidinecarboxylate

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Chemical Property of ethyl 4-<<3-(3-formyl-4-nitrophenoxy)propyl>sulfonyl>-1-piperidinecarboxylate

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Technology Process of ethyl 4-<<3-(3-formyl-4-nitrophenoxy)propyl>sulfonyl>-1-piperidinecarboxylate

There total 7 articles about ethyl 4-<<3-(3-formyl-4-nitrophenoxy)propyl>sulfonyl>-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 42454-06-8
2-nitro-5-hydroxybenzaldehyde

: 145624-47-1
1-(ethoxycarbonyl)-4-<(3-chloropropyl)sulfonyl>piperidine

: 145624-48-2
ethyl 4-<<3-(3-formyl-4-nitrophenoxy)propyl>sulfonyl>-1-piperidinecarboxylate

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 110 ℃; for 1.25h;
DOI:10.1021/jm00074a005

Reference yield:

: 1445-73-4
1-Methyl-4-piperidone

: 145624-48-2
ethyl 4-<<3-(3-formyl-4-nitrophenoxy)propyl>sulfonyl>-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 51 percent / H₂S / propan-2-ol / -5 - 5 °C

2: 81 percent / NaBH₄ / propan-2-ol / a) from 0 to 5 deg C, 0.5 h, b) RT, overnight, c) 80 deg C, 2 h

3: 87 percent / acetone / 2 h / Ambient temperature

4: 87 percent / toluene / 5 h / 110 °C

5: 1.) NaOEt / 1.) EtOH, RT, 3 h, 2.) EtOH, RT, 22 h

6: 100 percent / CH₃CO₃H / acetic acid; CH₂Cl₂ / 5 h / Ambient temperature

7: 91 percent / K₂CO₃, KI / dimethylformamide / 1.25 h / 110 °C

With peracetic acid; sodium tetrahydroborate; hydrogen sulfide; sodium ethanolate; potassium carbonate; potassium iodide; In dichloromethane; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; acetone; toluene;
DOI:10.1021/jm00074a005

Reference yield:

: 1072-99-7
1-methylpiperidine-4-thiol

: 145624-48-2
ethyl 4-<<3-(3-formyl-4-nitrophenoxy)propyl>sulfonyl>-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / acetone / 2 h / Ambient temperature

2: 87 percent / toluene / 5 h / 110 °C

3: 1.) NaOEt / 1.) EtOH, RT, 3 h, 2.) EtOH, RT, 22 h

4: 100 percent / CH₃CO₃H / acetic acid; CH₂Cl₂ / 5 h / Ambient temperature

5: 91 percent / K₂CO₃, KI / dimethylformamide / 1.25 h / 110 °C

With peracetic acid; sodium ethanolate; potassium carbonate; potassium iodide; In dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/jm00074a005